MK07_HUMAN_49_394

Mitogen-activated protein kinase 7 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MK07_HUMAN):R: Required for cytoplasmic targeting (61:66,69)
D: Protein kinase (61:66,69,82,84,98,115,137:143,145,146,186,189,199,200)
R: Required for binding to MAP2K5 (82,84,98,115,137:139)
R: Necessary for oligomerization (140:143,145,146,186,189,199,200)
61:66,69,82,84,98,115,137:143,145,146,186,189,199,200

Full PDB list

4b99,4ic7,4ic8,4zsg,4zsj,4zsl,5byy,5byz (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
I
6
1
G
6
2
N
6
3
G
6
4
A
6
5
Y
6
6
V
6
9
A
8
2
K
8
4
R
9
8
I
1
1
5
L
1
3
7
D
1
3
8
L
1
3
9
M
1
4
0
E
1
4
1
S
1
4
2
D
1
4
3
H
1
4
5
Q
1
4
6
S
1
8
6
L
1
8
9
G
1
9
9
D
2
0
0
[1]5byz.a 4we 34 . . . . . . . . . . . . . . . . . . . . . . . .
[2]4zsl.a none . . . . . . . . . . . . . . . . . . . . . . . .
[1]5byy.a 4wg 35 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4b99.a r4l 46 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ic7.d anp 31 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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