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MK07_HUMAN_49_394

Mitogen-activated protein kinase 7 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (MK07_HUMAN):R: Required for cytoplasmic targeting (61:67, 69)
D: Protein kinase (61:67, 69, 82, 84, 98, 115, 137:143, 145, 146, 186, 187, 189, 199, 200)
R: Required for binding to MAP2K5 (82, 84, 98, 115, 137:139)
R: Necessary for oligomerization (140:143, 145, 146, 186, 187, 189, 199, 200)
61:67, 69, 82, 84, 98, 115, 137:143, 145, 146, 186, 187, 189, 199, 200

Full PDB list

4b99, 4ic7, 4ic8, 4zsg, 4zsj, 4zsl, 5byy, 5byz (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
6
1
G
6
2
N
6
3
G
6
4
A
6
5
Y
6
6
V
6
9
A
8
2
K
8
4
R
9
8
I
1
1
5
L
1
3
7
D
1
3
8
L
1
3
9
M
1
4
0
E
1
4
1
S
1
4
2
D
1
4
3
H
1
4
5
Q
1
4
6
S
1
8
6
L
1
8
9
G
1
9
9
D
2
0
0
[1]4b99.a r4l46 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ic7.d anp31 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5byy.a 4wg35 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5byz.a 4we34 . . . . . . . . . . . . . . . . . . . . . . . .
[2]4zsl.a none . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
6
1
G
6
2
N
6
3
G
6
4
A
6
5
Y
6
6
G
6
7
V
6
9
A
8
2
K
8
4
R
9
8
I
1
1
5
L
1
3
7
D
1
3
8
L
1
3
9
M
1
4
0
E
1
4
1
S
1
4
2
D
1
4
3
H
1
4
5
Q
1
4
6
S
1
8
6
N
1
8
7
L
1
8
9
G
1
9
9
D
2
0
0
[1]4b99.a . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ic7.d . . . . . . . . . . . . . . . . . . . . * . . . . .
[1]5byy.a . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5byz.a . . . . . * . . . . . . . . . . . . . . * . . . . .
[2]4zsl.a . . * * * * * . . . . . . . . * . . . . * . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4b99.a:r4l
4ic7.d:anp
5byy.a:4wg
5byz.a:4we
4zsl.a is apo
[1] 4b99.a
0
0.1 0.1 0.5 -
[1] 4ic7.d 3.1
0.3
1.6 0.4 -
[1] 5byy.a 0.7 0.2
0.1
0.1 -
[1] 5byz.a 3.5 4.1 1.8
0
-
[2] 4zsl.a 12 11 10 9.7
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4b99.a
4ic7.d
5byy.a
5byz.a
4zsl.a
[1] 4b99.a
0
.13 .04 .26 .60
[1] 4ic7.d .13
0
.13 .21 .54
[1] 5byy.a .04 .13
0
.24 .60
[1] 5byz.a .26 .21 .24
0
.44
[2] 4zsl.a .60 .54 .60 .44
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4b99.a
4ic7.d
5byy.a
5byz.a
4zsl.a
[1] 4b99.a
0
1.1 0.9 1.0 3.1
[1] 4ic7.d 1.1
0
0.9 1.1 3.1
[1] 5byy.a 0.9 0.9
0
1.0 3.1
[1] 5byz.a 1.0 1.1 1.0
0
3.0
[2] 4zsl.a 3.1 3.1 3.1 3.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4b99.a
4ic7.d
5byy.a
5byz.a
4zsl.a
[1] 4b99.a
0
1.3 1.0 1.3 3.2
[1] 4ic7.d 1.3
0
1.2 2.3 3.6
[1] 5byy.a 1.0 1.2
0
1.3 2.8
[1] 5byz.a 1.3 2.3 1.3
0
3.3
[2] 4zsl.a 3.2 3.6 2.8 3.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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