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MK03_HUMAN_13_379

Mitogen-activated protein kinase 3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (MK03_HUMAN):D: Protein kinase (48:53, 56, 69, 71, 73, 81, 84, 85, 88, 101, 122:128, 131, 170, 173, 183, 184, 186)48:53, 56, 69, 71, 73, 81, 84, 85, 88, 101, 122:128, 131, 170, 173, 183, 184, 186
Metals (Me):Na

Full PDB list

2zoq, 4qtb

Pocket contact map

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PDB.ch
   
ligand
A1 Me
I
4
8
E
5
0
G
5
1
A
5
2
Y
5
3
V
5
6
A
6
9
K
7
1
I
7
3
Y
8
1
R
8
4
T
8
5
E
8
8
Q
1
2
2
D
1
2
3
L
1
2
4
M
1
2
5
E
1
2
6
T
1
2
7
K
1
3
1
S
1
7
0
L
1
7
3
C
1
8
3
D
1
8
4
G
1
8
6
[1]2zoq.a 5id20 . . . . . . . . . . . . . . . . . . . . . . . . . Na
[1]4qtb.a 38z44 . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 Me
I
4
8
G
4
9
E
5
0
G
5
1
A
5
2
Y
5
3
V
5
6
A
6
9
K
7
1
I
7
3
Y
8
1
R
8
4
T
8
5
E
8
8
I
1
0
1
Q
1
2
2
D
1
2
3
L
1
2
4
M
1
2
5
E
1
2
6
T
1
2
7
D
1
2
8
K
1
3
1
S
1
7
0
L
1
7
3
C
1
8
3
D
1
8
4
G
1
8
6
[1]2zoq.a . . . . . * . . * . * . . * . . . . . . . . . . . . * . Na
[1]4qtb.a . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2zoq.a:5id
4qtb.a:38z
[1] 2zoq.a
0.1
6.3
[1] 4qtb.a 0.2
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2zoq.a
4qtb.a
[1] 2zoq.a
0
.22
[1] 4qtb.a .22
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2zoq.a
4qtb.a
[1] 2zoq.a
0
1.0
[1] 4qtb.a 1.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2zoq.a
4qtb.a
[1] 2zoq.a
0
2.1
[1] 4qtb.a 2.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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