MCE_VACCW_1_302

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MCE_VACCW):R: Binding to NPH-I (177,180,182,202,204,205,207,233)
R: Binding to Rap94 (182,202,204,233)
R: mRNA cap binding (177,180)
R: mRNA cap binding (205,207)
22,24,27,148
22,24,27,148,177,180,182,202,204,205,207,233

Full PDB list

1av6,1b42,1bky,1eam,1eqa,1jsz,1jte,1jtf,1p39,1v39,1vp3,1vp9,1vpt,2ga9,2gaf,2vp3,3er8,3er9,3erc,3mag,3mct,4dcg (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
Y
2
2
P
2
4
A
2
7
P
1
4
8
R
1
7
7
F
1
8
0
D
1
8
2
P
2
0
2
Y
2
0
4
S
2
0
5
E
2
0
7
E
2
3
3
[1]1jsz.a ndm 13 . . . . . . . . . . . .
[1]1jtf.a m7g 28 . . . . . W . . . . . .
[1]1eqa.a mg7 21 . . . . . . . . . . . Q
[1]3mag.a 3ma 11 . . . . . . . . . . . .
[1]1b42.a m1a 11 . . . . . . . . . . . .
[1]1bky.a 1mc 9 . . . . . . . . . . . .
[1]1v39.a m7g 29 . . . . . . . . . . . .
[1]4dcg.a mg7 21 . . . . . . A . . . . .
[1]1p39.a mgt 32 . . . . . . . . . . . .
[1]1eam.a none . . - . . . . . . . . A
[1]1jte.a none . . . . . W . . . . . .
[1]3er8.a none . . - . . . . . . . . .
[1]3mct.a 3mc 9 . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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