M4K4_HUMAN_3_325

Mitogen-activated protein kinase kinase kinase kinase 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (M4K4_HUMAN):D: Protein kinase (31:36,39,41,52:54,103,105:109,111,112,115,153,155,157,158,160,170,171)31:36,39,41,52:54,103,105:109,111,112,115,153,155,157,158,160,170,171

Full PDB list

4obo,4obp,4obq,4rvt,4u3y,4u3z,4u40,4u41,4u42,4u43,4u44,4u45,4zk5,4zp5,5di1 (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
V
3
1
G
3
2
N
3
3
G
3
4
T
3
5
Y
3
6
V
3
9
K
4
1
A
5
2
I
5
3
K
5
4
L
1
0
3
M
1
0
5
E
1
0
6
F
1
0
7
C
1
0
8
G
1
0
9
G
1
1
1
S
1
1
2
D
1
1
5
D
1
5
3
K
1
5
5
Q
1
5
7
N
1
5
8
L
1
6
0
V
1
7
0
D
1
7
1
[1]4obq.a 2qt 27 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4zk5.a 4p4 30 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5di1.a 5df 24 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4u44.a 3d9 22 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4rvt.a 3xm 22 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4u41.a 3c8 23 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4u45.a 3dc 21 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4zp5.a 4qg 21 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4obp.a 2qu 18 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4obo.a 2qv 18 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4u43.a 3d8 16 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4u3y.a none . . . . . . . . . . . . . . . . . . . . . . . . . . .
[3]4u3z.b none - - - - . . . . . . . . . . . . . . . . . . . . . . .
[1]4u40.a anp,mg 32 . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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