M3K8_HUMAN_65_395

Mitogen-activated protein kinase kinase kinase 8 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (M3K8_HUMAN):D: Protein kinase (143:147,149,150,152,165,167,207:210,213,214,217,257,258,260,269,270)
132,134
132,134,143:147,149,150,152,165,167,207:210,213,214,217,257,258,260,269,270

Full PDB list

4y83,4y85,5iu2

Contact map

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ligand
A1
W
1
3
2
L
1
3
4
F
1
4
3
I
1
4
4
P
1
4
5
R
1
4
6
G
1
4
7
F
1
4
9
G
1
5
0
V
1
5
2
A
1
6
5
K
1
6
7
M
2
0
7
E
2
0
8
A
2
0
9
G
2
1
0
G
2
1
3
S
2
1
4
E
2
1
7
S
2
5
7
N
2
5
8
V
2
6
0
V
2
6
9
D
2
7
0
[1]4y85.a 499 24 . . . . . . . . . . . . . . . . . . . . . . . .
[2]4y83.a 49b 23 . . . . . . . . . . . . . . . . . . . . . . . .
[3]5iu2.a 6da 37 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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