M3K7_HUMAN_27_330

Mitogen-activated protein kinase kinase kinase 7 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (M3K7_HUMAN):R: Interaction with MAPK8IP1 (42:45,47,50,61:63,76,77,80,81,89,90,102,104:111,114,144,152:154,160,161,163,173:176)
D: Protein kinase (42:45,47,50,61:63,76,77,80,81,89,90,102,104:111,114,144,152:154,160,161,163,173:176)
42:45,47,50,61:63,76,77,80,81,89,90,102,104:111,114,144,152:154,160,161,163,173:176

Full PDB list

2eva,2yiy,4gs6,4l3p,4l52,4l53,4o91,5e7r,5gjd,5gjf,5gjg,5jgd5jga,5jgb (unprocessed)

Contact map

[download in TSV format]
   
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ligand
A1
V
4
2
G
4
3
R
4
4
G
4
5
F
4
7
V
5
0
A
6
1
I
6
2
K
6
3
V
7
6
E
7
7
Q
8
0
L
8
1
I
8
9
V
9
0
L
1
0
2
M
1
0
4
E
1
0
5
Y
1
0
6
A
1
0
7
E
1
0
8
G
1
0
9
G
1
1
0
S
1
1
1
N
1
1
4
L
1
4
4
L
1
5
2
I
1
5
3
H
1
5
4
P
1
6
0
N
1
6
1
L
1
6
3
I
1
7
3
C
1
7
4
D
1
7
5
F
1
7
6
[1]4l3p.a 1uh 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4l52.a 1ul 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4l53.a 1uo 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e7r.a 5kw 32 . . . - - . . . . - - - . . . . . . . . . . . . . . . . . . . . . * . .
[2]5jgd.a 6kd 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2yiy.a yiy 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5gjd.a 6v3 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4gs6.a 1fm 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . .
[1]4o91.a ng2 39 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5gjg.a 6v5 42 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5gjf.a 6v4 43 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2eva.a adn 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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