M3K5_HUMAN_661_945

Mitogen-activated protein kinase kinase kinase 5 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (M3K5_HUMAN):D: Protein kinase (686:689,694,707,709,738,752,754:761,807,808,810,814,821,822)686:689,694,707,709,738,752,754:761,807,808,810,814,821,822

Full PDB list

2clq,3vw6,4bf2,4bhn,4bib,4bic,4bid,4bie (redundant pocketome entry)

Contact map

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ligand
A1
L
6
8
6
G
6
8
7
K
6
8
8
G
6
8
9
V
6
9
4
A
7
0
7
K
7
0
9
V
7
3
8
I
7
5
2
M
7
5
4
E
7
5
5
Q
7
5
6
V
7
5
7
P
7
5
8
G
7
5
9
G
7
6
0
S
7
6
1
D
8
0
7
N
8
0
8
L
8
1
0
Y
8
1
4
S
8
2
1
D
8
2
2
[1]4bhn.a bh9 27 . . . . . . . . . . . . . . . . . . . . . . .
[1]4bid.a ie8 30 . . . . . . . . . . . . . . . . . . . . . . .
[1]3vw6.b im6 27 . . . . . . . . . . . . . . . . . . . . . . .
[1]4bie.a ie6 22 . . . . . . . . . . . . . . . . . . . . . . .
[1]4bic.a ie4 21 . . . . . . . . . . . . . . . . . . . . . . .
[1]4bib.a ieo 21 . . . . . . . . . . . . . . . . . . . . . . .
[1]4bf2.a stu 35 . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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