M3K12_HUMAN_113_402

Mitogen-activated protein kinase kinase kinase 12 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (M3K12_HUMAN):D: Protein kinase (131:134,136,139,150,174,190:197,243)131:134,136,139,150,174,190:197,243

Full PDB list

5cen,5ceo,5cep,5ceq

Contact map

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ligand
A1
V
1
3
1
G
1
3
2
S
1
3
3
G
1
3
4
Q
1
3
6
V
1
3
9
A
1
5
0
I
1
7
4
M
1
9
0
E
1
9
1
F
1
9
2
C
1
9
3
A
1
9
4
Q
1
9
5
G
1
9
6
Q
1
9
7
L
2
4
3
[1]5ceo.a 50d 32 . . . . . . . . . . . . . . . . .
[1]5ceq.a 50f 29 . . . . . . . . . . . . . . . . .
[1]5cep.a 50e 25 . . . . . . . . . . . . . . . . .
[1]5cen.a none . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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