LCK_HUMAN_122_227

Tyrosine-protein kinase Lck [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (LCK_HUMAN):D: SH2 (134,154,156:158,164,179:182,184,193:196,209,214:217)
R: Interaction with PTPRH (154,156:158,164,179:182,184,193:196,209,214:217)
134,154,156:158,164,179:182,184,193:196,209,214:217

Full PDB list

1bhf,1bhh,1cwd,1cwe,1fbz,1ijr,1lcj,1lck,1lkk,1lkl,1x27,4d8k (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
R
1
3
4
R
1
5
4
S
1
5
6
E
1
5
7
S
1
5
8
S
1
6
4
K
1
7
9
H
1
8
0
Y
1
8
1
K
1
8
2
R
1
8
4
I
1
9
3
S
1
9
4
P
1
9
5
R
1
9
6
Y
2
0
9
D
2
1
4
G
2
1
5
L
2
1
6
C
2
1
7
[1]1ijr.a cc0 43 . . . . . C . . . . . . . . . . . . . .
[1]1fbz.a cc1 45 . . . . . C . . . . . . . . . . . . . .
[1]1bhf.a ace.1paEEI 45 . . . . . . . . . . . . . . . . . . . .
[1]1bhh.a none . . . . . . . . . . . . . . . . . . . .
[1]1cwd.l EGDpm3EEVL 71 . . . . . . . . . . . . . . . . . . . .
[1]1cwe.a Qpm3EEIP 59 . . . . . . . . . . . . . . . . . . . .
[1]1lcj.a EPQptrEEIPIYL 103 . . . . . . . . . . . . . . . . . . . .
[1]1lck.a EGQptrQPQPA 76 . . . . . . . . . . . . . . . . . . . .
[1]1lkk.a ace.ptrEEI 45 . . . . . . . . . . . . . . . . . . . .
[1]1lkl.a ace.ptrEEG 42 . . . . . . . . . . . . . . . . . . . .
[1]1x27.a DptrDYV 51 . . . . . . . . . . . . . . . . . . . .
[1]1x27.b DptrDYVH 61 . . . . . . . . . . . . . . . . . . . .
[1]1x27.c ptrDYVH 53 . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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