KS6B1_HUMAN_76_373

Ribosomal protein S6 kinase beta-1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (KS6B1_HUMAN):D: Protein kinase (97:105,121,123,125,143,156,172:175,179,222,225,235,236,239:241)97:105,121,123,125,143,156,172:175,179,222,225,235,236,239:241
Metals (Me):Mn/Zn

Full PDB list

3a60,3a61,3a62,3we4,3wf5,3wf6,3wf7,3wf8,3wf9,4l3j,4l3l,4l42,4l43,4l44,4l45,4l46,4rlo,4rlp (redundant pocketome entry)

Contact map

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ligand
A1 Me
L
9
7
G
9
8
K
9
9
G
1
0
0
G
1
0
1
Y
1
0
2
G
1
0
3
K
1
0
4
V
1
0
5
A
1
2
1
K
1
2
3
L
1
2
5
E
1
4
3
V
1
5
6
L
1
7
2
E
1
7
3
Y
1
7
4
L
1
7
5
E
1
7
9
E
2
2
2
M
2
2
5
T
2
3
5
D
2
3
6
L
2
3
9
C
2
4
0
K
2
4
1
[1]3wf8.a f76 32 . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3wf9.a fs7 33 . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3wf7.a fs9 28 . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3wf5.a fz8 24 . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3wf6.a fz9 24 . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4rlp.a 72b 41 . . . . . . . . . . . . - . . . . . . . . . . . . .
[1]3a62.a stu 35 . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]4l42.a 5fi 28 . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4rlo.a 3t3 37 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4l45.a 5fi 28 . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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