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KS6A5_HUMAN_414_738_ATPsite

Ribosomal protein S6 kinase alpha-5 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (KS6A5_HUMAN):D: Protein kinase 2 (432:435, 440, 453, 498:501, 505, 548, 551, 564)
716
432:435, 440, 453, 498:501, 505, 548, 551, 564, 716

Full PDB list

3kn5, 3kn6

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
4
3
2
G
4
3
3
E
4
3
4
A
4
5
3
E
4
9
9
L
5
0
0
L
5
0
1
E
5
0
5
E
5
4
8
L
5
5
1
I
5
6
4
K
7
1
6
[1]3kn5.a anp31 . . . . . . . . . . . .
[1]3kn6.a none . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
4
3
2
G
4
3
3
E
4
3
4
G
4
3
5
C
4
4
0
A
4
5
3
M
4
9
8
E
4
9
9
L
5
0
0
L
5
0
1
E
5
0
5
E
5
4
8
L
5
5
1
I
5
6
4
K
7
1
6
[1]3kn5.a . . . . . . . . . . . . . . .
[1]3kn6.a . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3kn5.a:anp
3kn6.a is apo
[1] 3kn5.a
0
-
[1] 3kn6.a 0
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3kn5.a
3kn6.a
[1] 3kn5.a
0
0
[1] 3kn6.a 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3kn5.a
3kn6.a
[1] 3kn5.a
0
0.2
[1] 3kn6.a 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3kn5.a
3kn6.a
[1] 3kn5.a
0
0.3
[1] 3kn6.a 0.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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