If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

KLK7_HUMAN_30_252

Kallikrein-7 [Peptidase S1 family. Kallikrein subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (KLK7_HUMAN):D: Peptidase S1 (52:55, 70, 71, 109, 157, 159, 183, 199:205, 219:224, 226, 228, 233, 234)52:55, 70, 71, 109, 157, 159, 183, 199:205, 219:224, 226, 228, 233, 234

Full PDB list

2qxg, 2qxh, 2qxi, 2qxj, 3bsq, 5fah, 5y9l, 5yjk (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
Q
5
2
L
5
3
H
5
4
C
5
5
H
7
0
C
7
1
H
1
0
9
F
1
5
9
L
1
8
3
A
2
0
0
C
2
0
1
N
2
0
2
G
2
0
3
D
2
0
4
S
2
0
5
V
2
1
9
S
2
2
0
W
2
2
1
G
2
2
2
T
2
2
3
F
2
2
4
C
2
2
6
G
2
3
3
V
2
3
4
[1]2qxg.b k7i22 . . . . * . . . . . . . . . * . . . . . . . . .
[1]2qxh.a k7j36 . . . . * . . . . . . . . . * . . . . . . . . .
[1]3bsq.a none . . . . . . . . . . . . . . . . . . . . . . . .
[1]5fah.a 5vt32 . . . . . . . . - . . . . . . . . . . . . . . .
[1]5y9l.a 8r335 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5yjk.a 8vx36 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
Q
5
2
L
5
3
H
5
4
C
5
5
H
7
0
C
7
1
H
1
0
9
V
1
5
7
F
1
5
9
L
1
8
3
N
1
9
9
A
2
0
0
C
2
0
1
N
2
0
2
G
2
0
3
D
2
0
4
S
2
0
5
V
2
1
9
S
2
2
0
W
2
2
1
G
2
2
2
T
2
2
3
F
2
2
4
C
2
2
6
Q
2
2
8
G
2
3
3
V
2
3
4
[1]2qxg.b . . . . * . . . . . . . . * . . * . . . . . . . . . .
[1]2qxh.a . . . . * . . . . . . . . . . . * . . . . . . . . . .
[1]3bsq.a . . . . . . . . . . . . . . . . * . . . . . . . . . .
[1]5fah.a . . . . . . . . . - . . . . . . . . . . . . . . . . .
[1]5y9l.a . . . . . . . . . . . . . . . . * . . . . . . . . . .
[1]5yjk.a . . . . . . . . . . . . . . . . * . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2qxg.b:k7i
2qxh.a:k7j
3bsq.a is apo
5fah.a:5vt
5y9l.a:8r3
5yjk.a:8vx
[1] 2qxg.b
1.5
1.2 - 0.7 0.8 1.1
[1] 2qxh.a 1.5
1.5
- 0.7 0.3 0.5
[1] 3bsq.a 1.6 1.5
-
1.0 0.8 1.0
[1] 5fah.a 0.6 1.6 -
0
1.1 1.2
[1] 5y9l.a 1.3 1.2 - 0.4
0
0
[1] 5yjk.a 1.5 1.2 - 0.7 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2qxg.b
2qxh.a
3bsq.a
5fah.a
5y9l.a
5yjk.a
[1] 2qxg.b
0
.04 .08 .07 .06 .06
[1] 2qxh.a .04
0
.06 .06 .03 .03
[1] 3bsq.a .08 .06
0
.08 .05 .04
[1] 5fah.a .07 .06 .08
0
.08 .08
[1] 5y9l.a .06 .03 .05 .08
0
.01
[1] 5yjk.a .06 .03 .04 .08 .01
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2qxg.b
2qxh.a
3bsq.a
5fah.a
5y9l.a
5yjk.a
[1] 2qxg.b
0
0.4 0.6 0.5 0.4 0.4
[1] 2qxh.a 0.4
0
0.5 0.5 0.4 0.4
[1] 3bsq.a 0.6 0.5
0
0.6 0.5 0.5
[1] 5fah.a 0.5 0.5 0.6
0
0.6 0.6
[1] 5y9l.a 0.4 0.4 0.5 0.6
0
0.2
[1] 5yjk.a 0.4 0.4 0.5 0.6 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2qxg.b
2qxh.a
3bsq.a
5fah.a
5y9l.a
5yjk.a
[1] 2qxg.b
0
0.9 1.3 1.3 1.0 0.9
[1] 2qxh.a 0.9
0
1.2 1.1 0.7 0.8
[1] 3bsq.a 1.3 1.2
0
1.5 1.2 1.2
[1] 5fah.a 1.3 1.1 1.5
0
1.1 1.1
[1] 5y9l.a 1.0 0.7 1.2 1.1
0
0.5
[1] 5yjk.a 0.9 0.8 1.2 1.1 0.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...