JAK2_HUMAN_536_835_ATPsite

Tyrosine-protein kinase JAK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (JAK2_HUMAN):D: Protein kinase 1 (551,554,555,557,559,579,581,626:629,633,673,677,678,680)551,554,555,557,559,579,581,626:629,633,673,677,678,680
Metals (Me):Mg

Full PDB list

4fvp,4fvq,4fvr,5i4n (redundant pocketome entry)

Contact map

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ligand
A1 Me
L
5
5
1
G
5
5
4
T
5
5
5
T
5
5
7
I
5
5
9
L
5
7
9
K
5
8
1
Q
6
2
6
E
6
2
7
F
6
2
8
V
6
2
9
S
6
3
3
N
6
7
3
K
6
7
7
N
6
7
8
L
6
8
0
[1]4fvq.a atp 31 . . . . . . . . . . . . . . . . Mg
[1]4fvp.a none . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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