JAK1_HUMAN_854_1154

Tyrosine-protein kinase JAK1 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (JAK1_HUMAN):D: Protein kinase 2 (879,881:884,887:889,906,908,938,956:960,962,963,966,1003,1007,1008,1010,1020,1021)879,881:884,887:889,906,908,938,956:960,962,963,966,1003,1007,1008,1010,1020,1021

Full PDB list

3eyg,3eyh,4e4l,4e4n,4e5w,4ehz,4ei4,4fk6,4i5c,4ivb,4ivc,4ivd,4k6z,4k77,5e1e,5hx8,5khw,5khx

Contact map

[download in TSV format]
   
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ligand
A1
R
8
7
9
L
8
8
1
G
8
8
2
E
8
8
3
G
8
8
4
G
8
8
7
K
8
8
8
V
8
8
9
A
9
0
6
K
9
0
8
V
9
3
8
M
9
5
6
E
9
5
7
F
9
5
8
L
9
5
9
P
9
6
0
G
9
6
2
S
9
6
3
E
9
6
6
D
1
0
0
3
R
1
0
0
7
N
1
0
0
8
L
1
0
1
0
G
1
0
2
0
D
1
0
2
1
[1]4e5w.a 0nt 28 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e1e.a 5jg 29 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4e4n.a 0nl 25 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4fk6.b 0uj 25 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ivd.a 15t 25 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ivc.b 1j6 24 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4k6z.a 1q3 24 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5hx8.a 66p 24 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4i5c.b c5i 23 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4e4l.b 0nh 23 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ivb.a 1j5 23 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ei4.b 0q2 20 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5khx.a 6te 20 . . . - - - . . . . . . . . . . . . . . . . . . .
[1]4k77.b 1q4 18 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ehz.b jak 19 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3eyh.a iza 23 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3eyg.a mi1 23 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5khw.b adp,mg 28 . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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