IRAK4_HUMAN_158_460

Interleukin-1 receptor-associated kinase 4 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (IRAK4_HUMAN):D: Protein kinase (192:197,200,211,213,233,246,262:269,272,273,280,313,315,316,318,328,329)
185
185,192:197,200,211,213,233,246,262:269,272,273,280,313,315,316,318,328,329

Full PDB list

2nru,2nry,2o8y,2oib,2oic,2oid,4rmz,4u97,4u9a,4xs2,4y73,4yo6,4yp8,4ztl,4ztm,4ztn,5kx7,5kx8 (redundant pocketome entry)

Contact map

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ligand
A1
I
1
8
5
M
1
9
2
G
1
9
3
E
1
9
4
G
1
9
5
G
1
9
6
F
1
9
7
V
2
0
0
A
2
1
1
K
2
1
3
E
2
3
3
V
2
4
6
Y
2
6
2
V
2
6
3
Y
2
6
4
M
2
6
5
P
2
6
6
N
2
6
7
G
2
6
8
S
2
6
9
D
2
7
2
R
2
7
3
T
2
8
0
K
3
1
3
A
3
1
5
N
3
1
6
L
3
1
8
S
3
2
8
D
3
2
9
[1]4xs2.c 42p 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ztl.a 4s1 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ztm.c 4s2 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ztn.a 4s3 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5kx8.b 6ye 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2nru.c t12 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4rmz.a unl 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4y73.d xpy 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yo6.b 4gd 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yp8.d 4gf 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5kx7.a none - . . . . . . . . - . . . . . . . . . . . . . . . . . . .
[1]5kx7.b 6yd 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2nry.b stu 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2o8y.b none . * . . . . . . . . . . . . . * . . . . . . . . . . . . .
[1]4u97.a stu 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2oid.d anp 31 . . . . . - . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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