If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

HCK_HUMAN_246_526

Tyrosine-protein kinase HCK [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (HCK_HUMAN):D: Protein kinase (268:271, 276, 288:290, 297, 302:307, 309, 318, 320, 331, 333:336, 339, 340, 342, 343, 383, 385:388, 398:402, 405)268:271, 276, 288:290, 297, 302:307, 309, 318, 320, 331, 333:336, 339, 340, 342, 343, 383, 385:388, 398:402, 405

Full PDB list

1ad5, 1qcf, 2c0i, 2c0o, 2c0t, 2hck, 2hk5, 3vry, 3vrz, 3vs0, 3vs1, 3vs2, 3vs3, 3vs4, 3vs5, 3vs6, 3vs7, 4lud, 4lue, 5h09, 5h0b, 5h0e, 5h0g, 5h0h (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
2
6
8
G
2
6
9
A
2
7
0
G
2
7
1
V
2
7
6
A
2
8
8
V
2
8
9
K
2
9
0
F
3
0
2
E
3
0
5
A
3
0
6
M
3
0
9
V
3
1
8
L
3
2
0
I
3
3
1
T
3
3
3
E
3
3
4
F
3
3
5
M
3
3
6
G
3
3
9
S
3
4
0
D
3
4
3
A
3
8
5
N
3
8
6
L
3
8
8
A
3
9
8
D
3
9
9
F
4
0
0
G
4
0
1
L
4
0
2
[1]1ad5.a anp,ca32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1qcf.a pp121 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2c0i.a l1g44 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2c0o.a l2g46 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2c0t.a ca,l3g44 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2hck.a que22 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2hk5.a 1bm32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vry.a b4328 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vrz.a vrz32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs0.b vs030 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs1.b vsa31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs2.a vsb36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs3.a vse36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs4.a vsf29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs5.a vsg30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs6.a vsh29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs7.a ks124 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4lud.a sk821 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4lud.b ca,sk822 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5h09.a ooo40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5h0b.a ooq38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5h0e.a oos38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5h0g.a oou39 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5h0h.a oov40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
2
6
8
G
2
6
9
A
2
7
0
G
2
7
1
V
2
7
6
A
2
8
8
V
2
8
9
K
2
9
0
M
2
9
7
F
3
0
2
L
3
0
3
A
3
0
4
E
3
0
5
A
3
0
6
N
3
0
7
M
3
0
9
V
3
1
8
L
3
2
0
I
3
3
1
T
3
3
3
E
3
3
4
F
3
3
5
M
3
3
6
G
3
3
9
S
3
4
0
L
3
4
2
D
3
4
3
R
3
8
3
A
3
8
5
N
3
8
6
I
3
8
7
L
3
8
8
A
3
9
8
D
3
9
9
F
4
0
0
G
4
0
1
L
4
0
2
V
4
0
5
[1]1ad5.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . * . . . .
[1]1qcf.a . . * . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]2c0i.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2c0o.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . .
[1]2c0t.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2hck.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . * . . . .
[1]2hk5.a . . . . . . . . . . . . * * . * . . . . . . . . . . . . . . . . . . . . . .
[1]3vry.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]3vrz.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs0.b . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3vs1.b . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . .
[1]3vs2.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . * . . . .
[1]3vs3.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]3vs4.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]3vs5.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . * . . . . . . . .
[1]3vs6.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]3vs7.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4lud.a . . . . . . . . - . . . . . . * . . . . . . . . . . . . . . . . . . . . * .
[1]4lud.b . . . . . . . . - . . . . . . * . . . . . . . . . . . . . . . . . . . . * .
[1]5h09.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]5h0b.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]5h0e.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]5h0g.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .
[1]5h0h.a . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1ad5.a:anp,ca
1qcf.a:pp1
2c0i.a:l1g
2c0o.a:l2g
2c0t.a:ca,l3g
2hck.a:que
2hk5.a:1bm
3vry.a:b43
3vrz.a:vrz
3vs0.b:vs0
3vs1.b:vsa
3vs2.a:vsb
3vs3.a:vse
3vs4.a:vsf
3vs5.a:vsg
3vs6.a:vsh
3vs7.a:ks1
4lud.a:sk8
4lud.b:ca,sk8
5h09.a:ooo
5h0b.a:ooq
5h0e.a:oos
5h0g.a:oou
5h0h.a:oov
[1] 1ad5.a
0.2
0.1 1.8 1.4 1.6 0 2.0 0.4 1.6 0.7 1.0 0.4 0.3 0.4 0.5 1.1 0.3 0.1 0.2 0.7 0.7 0.5 0.7 0.7
[1] 1qcf.a 0.2
0
1.7 1.4 1.6 0.1 1.7 0.1 1.7 0.3 0.8 0.6 0.2 0 0.1 0.2 0 0.1 0.1 0.1 0 0 0.1 0
[1] 2c0i.a 0.5 0
0
0 0.3 0.1 1.0 0 0.1 0 0.1 0.1 0 0 0 0.2 0 0.1 0.3 0.1 0.2 0.1 0.1 0.2
[1] 2c0o.a 0.8 0 0
0
0.4 0.1 1.4 0 0 0 0.2 0.2 0 0.1 0 0.2 0.1 0 0.2 0.3 0.1 0.3 0.2 0.2
[1] 2c0t.a 0.5 0 0 0
0.2
0.1 0.7 0 0 0 0 0.2 0 0 0 0.1 0 0 0.2 0.1 0.1 0.1 0.1 0.1
[1] 2hck.a 0.8 0.3 2.2 1.5 2.2
0
2.6 0.8 1.5 0.4 0.8 0.8 0.9 0.7 0.9 0.9 0.5 0.2 0.5 1.5 1.6 1.5 1.1 1.6
[1] 2hk5.a 0 0 4.6 5.0 4.6 0.2
0
1.7 4.0 2.0 3.0 1.3 1.8 1.7 1.2 1.4 0 0.1 0.2 1.4 1.4 1.4 1.3 1.5
[1] 3vry.a 0.5 0 1.7 1.4 1.7 0.1 1.2
0
1.5 0.2 0.6 0 0.2 0 0 0.4 0 0 0.3 0.1 0 0 0.1 0.1
[1] 3vrz.a 0.3 0 0.3 0.1 0.4 0 0.9 0
0
0 0.1 0 0 0 0 0.4 0.1 0.1 0.3 0.2 0 0.1 0 0.1
[1] 3vs0.b 0.1 0 0.5 0.3 0.5 0.1 1.0 0.6 0.2
0
0.1 0.3 0.5 0.6 0.5 0.7 0.1 0 0.2 0.5 0.4 0.5 0.5 0.4
[1] 3vs1.b 0 0 1.5 0.9 1.1 0 1.2 1.6 0 0.3
0
1.5 1.9 1.4 1.7 1.4 0.1 0.2 0 1.9 1.9 1.9 1.9 1.9
[1] 3vs2.a 0.8 0 1.0 1.0 1.2 0.1 1.3 0 1.3 0.2 0.6
0
0 0 0 0 0.1 0.1 0.3 0 0 0 0 0
[1] 3vs3.a 0.5 0 1.7 1.5 1.7 0.1 1.2 0 1.4 0.7 0.8 0
0
0 0 0.3 0 0.2 0.3 0 0.1 0 0 0.1
[1] 3vs4.a 0.6 0 1.6 1.3 1.9 0.1 1.4 0 1.8 0.5 0.8 0 0
0
0.1 0.2 0.1 0.1 0.4 0.1 0.1 0.1 0 0.1
[1] 3vs5.a 0.5 0 1.6 1.4 2.0 0.1 1.8 0 1.8 0.5 0.9 0 0 0
0
0.2 0.2 0.1 0.5 0.3 0.2 0.3 0.3 0.3
[1] 3vs6.a 0.5 0 1.1 0.9 1.4 0 1.1 0 1.6 0.3 0.7 0 0 0 0
0
0 0 0.2 0.1 0.1 0.2 0.2 0.1
[1] 3vs7.a 0.4 0 0.3 0.3 0.5 0 0.8 0.1 0.2 0.1 0.1 0 0.1 0 0.1 0.1
0
0 0.2 0.2 0.3 0.2 0.3 0.2
[1] 4lud.a 0 0 2.3 1.9 2.0 0 1.3 0.6 1.5 1.1 1.4 0.5 0.4 0.6 0.5 0.8 0
0
0.1 0.7 0.6 0.7 0.6 0.6
[1] 4lud.b 0.4 0.1 1.9 1.8 1.9 0 1.7 0.2 2.1 0.9 1.2 0.3 0.3 0.2 0.2 0.4 0.1 0
0.2
0.4 0.3 0.3 0.2 0.3
[1] 5h09.a 0.2 0 1.6 1.4 2.0 0.1 1.3 0 1.7 0.4 1.0 0 0 0 0.1 0.5 0.1 0.2 0.2
0
0 0 0 0
[1] 5h0b.a 0.2 0 1.6 1.4 1.4 0.1 1.2 0 1.5 0.4 0.9 0 0.1 0 0.1 0.3 0.1 0.1 0.2 0
0
0 0.1 0.1
[1] 5h0e.a 0.2 0 1.6 1.4 1.8 0.1 1.1 0 1.5 0.3 0.9 0 0 0 0.2 0.5 0 0.2 0.3 0 0
0
0 0
[1] 5h0g.a 0.3 0 1.6 1.2 1.6 0.1 1.1 0 1.5 0.3 1.1 0 0 0 0.1 0.2 0 0.1 0.2 0 0 0
0
0
[1] 5h0h.a 0.2 0 1.6 1.4 1.7 0.1 1.3 0 1.5 0.4 0.8 0 0.1 0 0.3 0.4 0.1 0.2 0.2 0 0 0 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1ad5.a
1qcf.a
2c0i.a
2c0o.a
2c0t.a
2hck.a
2hk5.a
3vry.a
3vrz.a
3vs0.b
3vs1.b
3vs2.a
3vs3.a
3vs4.a
3vs5.a
3vs6.a
3vs7.a
4lud.a
4lud.b
5h09.a
5h0b.a
5h0e.a
5h0g.a
5h0h.a
[1] 1ad5.a
0
.08 .07 .07 .07 .06 .17 .07 .08 .07 .05 .05 .06 .07 .08 .06 .07 .07 .06 .08 .08 .07 .07 .07
[1] 1qcf.a .08
0
.09 .08 .10 .09 .19 .06 .11 .09 .11 .05 .05 .05 .05 .05 .09 .08 .08 .06 .05 .05 .06 .05
[1] 2c0i.a .07 .09
0
.02 .01 .11 .17 .07 .04 .03 .05 .06 .07 .07 .09 .06 .03 .07 .08 .07 .06 .06 .06 .06
[1] 2c0o.a .07 .08 .02
0
.02 .10 .19 .06 .04 .03 .05 .05 .07 .06 .08 .05 .03 .08 .09 .07 .07 .07 .07 .07
[1] 2c0t.a .07 .10 .01 .02
0
.12 .17 .07 .03 .03 .06 .06 .07 .08 .09 .06 .02 .08 .09 .08 .07 .07 .07 .07
[1] 2hck.a .06 .09 .11 .10 .12
0
.22 .09 .11 .11 .09 .09 .09 .09 .09 .09 .11 .11 .10 .11 .11 .10 .11 .10
[1] 2hk5.a .17 .19 .17 .19 .17 .22
0
.16 .19 .18 .22 .16 .15 .17 .18 .16 .18 .18 .20 .17 .17 .17 .16 .17
[1] 3vry.a .07 .06 .07 .06 .07 .09 .16
0
.06 .06 .10 .03 .02 .02 .04 .04 .06 .07 .08 .04 .05 .04 .04 .04
[1] 3vrz.a .08 .11 .04 .04 .03 .11 .19 .06
0
.03 .06 .07 .08 .07 .09 .07 .04 .10 .10 .08 .08 .07 .07 .07
[1] 3vs0.b .07 .09 .03 .03 .03 .11 .18 .06 .03
0
.06 .05 .06 .06 .07 .06 .03 .09 .08 .06 .06 .05 .06 .06
[1] 3vs1.b .05 .11 .05 .05 .06 .09 .22 .10 .06 .06
0
.08 .09 .09 .12 .09 .06 .10 .09 .10 .10 .09 .10 .09
[1] 3vs2.a .05 .05 .06 .05 .06 .09 .16 .03 .07 .05 .08
0
.02 .02 .04 .03 .06 .06 .07 .04 .04 .03 .04 .03
[1] 3vs3.a .06 .05 .07 .07 .07 .09 .15 .02 .08 .06 .09 .02
0
.02 .04 .03 .07 .05 .07 .04 .04 .03 .04 .03
[1] 3vs4.a .07 .05 .07 .06 .08 .09 .17 .02 .07 .06 .09 .02 .02
0
.03 .03 .07 .06 .06 .03 .03 .02 .03 .02
[1] 3vs5.a .08 .05 .09 .08 .09 .09 .18 .04 .09 .07 .12 .04 .04 .03
0
.04 .08 .07 .06 .05 .06 .05 .05 .05
[1] 3vs6.a .06 .05 .06 .05 .06 .09 .16 .04 .07 .06 .09 .03 .03 .03 .04
0
.05 .04 .05 .04 .05 .04 .04 .04
[1] 3vs7.a .07 .09 .03 .03 .02 .11 .18 .06 .04 .03 .06 .06 .07 .07 .08 .05
0
.07 .08 .07 .07 .06 .06 .07
[1] 4lud.a .07 .08 .07 .08 .08 .11 .18 .07 .10 .09 .10 .06 .05 .06 .07 .04 .07
0
.04 .07 .07 .06 .07 .07
[1] 4lud.b .06 .08 .08 .09 .09 .10 .20 .08 .10 .08 .09 .07 .07 .06 .06 .05 .08 .04
0
.06 .06 .05 .06 .06
[1] 5h09.a .08 .06 .07 .07 .08 .11 .17 .04 .08 .06 .10 .04 .04 .03 .05 .04 .07 .07 .06
0
.01 .01 .02 .01
[1] 5h0b.a .08 .05 .06 .07 .07 .11 .17 .05 .08 .06 .10 .04 .04 .03 .06 .05 .07 .07 .06 .01
0
.01 .01 .01
[1] 5h0e.a .07 .05 .06 .07 .07 .10 .17 .04 .07 .05 .09 .03 .03 .02 .05 .04 .06 .06 .05 .01 .01
0
.01 .01
[1] 5h0g.a .07 .06 .06 .07 .07 .11 .16 .04 .07 .06 .10 .04 .04 .03 .05 .04 .06 .07 .06 .02 .01 .01
0
.01
[1] 5h0h.a .07 .05 .06 .07 .07 .10 .17 .04 .07 .06 .09 .03 .03 .02 .05 .04 .07 .07 .06 .01 .01 .01 .01
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1ad5.a
1qcf.a
2c0i.a
2c0o.a
2c0t.a
2hck.a
2hk5.a
3vry.a
3vrz.a
3vs0.b
3vs1.b
3vs2.a
3vs3.a
3vs4.a
3vs5.a
3vs6.a
3vs7.a
4lud.a
4lud.b
5h09.a
5h0b.a
5h0e.a
5h0g.a
5h0h.a
[1] 1ad5.a
0
1.3 1.5 1.5 1.5 0.7 3.9 1.4 1.5 1.3 1.4 1.3 1.3 1.4 1.3 1.3 1.4 1.2 1.3 1.4 1.4 1.4 1.4 1.4
[1] 1qcf.a 1.3
0
1.1 1.0 1.1 1.4 3.3 0.9 0.9 0.9 1.1 0.7 0.7 0.8 0.8 0.8 1.0 0.9 0.7 0.5 0.4 0.5 0.6 0.5
[1] 2c0i.a 1.5 1.1
0
0.3 0.2 1.6 3.2 0.7 0.5 0.7 0.8 0.6 0.7 0.6 0.7 0.6 0.9 0.6 0.6 0.9 1.0 0.9 0.9 1.0
[1] 2c0o.a 1.5 1.0 0.3
0
0.3 1.5 3.2 0.6 0.5 0.7 0.7 0.6 0.7 0.6 0.6 0.6 0.8 0.6 0.6 1.0 1.0 0.9 0.9 1.0
[1] 2c0t.a 1.5 1.1 0.2 0.3
0
1.6 3.1 0.7 0.5 0.7 0.8 0.6 0.7 0.6 0.7 0.7 0.8 0.6 0.6 1.0 1.0 1.0 1.0 1.0
[1] 2hck.a 0.7 1.4 1.6 1.5 1.6
0
4.0 1.4 1.5 1.4 1.4 1.3 1.4 1.5 1.3 1.3 1.4 1.3 1.4 1.4 1.4 1.4 1.5 1.4
[1] 2hk5.a 3.9 3.3 3.2 3.2 3.1 4.0
0
3.3 3.3 3.4 3.3 3.2 3.2 3.2 3.3 3.3 3.2 3.2 3.1 3.3 3.3 3.3 3.2 3.3
[1] 3vry.a 1.4 0.9 0.7 0.6 0.7 1.4 3.3
0
0.6 0.8 0.8 0.6 0.7 0.4 0.5 0.5 0.9 0.5 0.4 0.9 0.9 0.8 0.9 0.9
[1] 3vrz.a 1.5 0.9 0.5 0.5 0.5 1.5 3.3 0.6
0
0.6 0.7 0.6 0.7 0.5 0.6 0.6 0.8 0.6 0.6 0.9 0.9 0.8 0.9 0.9
[1] 3vs0.b 1.3 0.9 0.7 0.7 0.7 1.4 3.4 0.8 0.6
0
0.8 0.6 0.7 0.7 0.7 0.7 0.8 0.7 0.7 0.8 0.8 0.8 0.8 0.8
[1] 3vs1.b 1.4 1.1 0.8 0.7 0.8 1.4 3.3 0.8 0.7 0.8
0
0.8 0.9 0.8 0.8 0.8 0.9 0.6 0.7 1.1 1.1 1.1 1.1 1.1
[1] 3vs2.a 1.3 0.7 0.6 0.6 0.6 1.3 3.2 0.6 0.6 0.6 0.8
0
0.4 0.4 0.4 0.4 0.7 0.5 0.4 0.6 0.6 0.6 0.6 0.6
[1] 3vs3.a 1.3 0.7 0.7 0.7 0.7 1.4 3.2 0.7 0.7 0.7 0.9 0.4
0
0.5 0.5 0.5 0.8 0.6 0.5 0.6 0.6 0.6 0.6 0.6
[1] 3vs4.a 1.4 0.8 0.6 0.6 0.6 1.5 3.2 0.4 0.5 0.7 0.8 0.4 0.5
0
0.4 0.5 0.8 0.5 0.4 0.7 0.7 0.7 0.7 0.8
[1] 3vs5.a 1.3 0.8 0.7 0.6 0.7 1.3 3.3 0.5 0.6 0.7 0.8 0.4 0.5 0.4
0
0.3 0.7 0.5 0.5 0.7 0.7 0.7 0.7 0.7
[1] 3vs6.a 1.3 0.8 0.6 0.6 0.7 1.3 3.3 0.5 0.6 0.7 0.8 0.4 0.5 0.5 0.3
0
0.7 0.5 0.4 0.7 0.7 0.7 0.7 0.7
[1] 3vs7.a 1.4 1.0 0.9 0.8 0.8 1.4 3.2 0.9 0.8 0.8 0.9 0.7 0.8 0.8 0.7 0.7
0
0.7 0.8 0.9 0.9 0.9 0.9 0.9
[1] 4lud.a 1.2 0.9 0.6 0.6 0.6 1.3 3.2 0.5 0.6 0.7 0.6 0.5 0.6 0.5 0.5 0.5 0.7
0
0.4 0.8 0.8 0.8 0.8 0.8
[1] 4lud.b 1.3 0.7 0.6 0.6 0.6 1.4 3.1 0.4 0.6 0.7 0.7 0.4 0.5 0.4 0.5 0.4 0.8 0.4
0
0.6 0.6 0.6 0.6 0.6
[1] 5h09.a 1.4 0.5 0.9 1.0 1.0 1.4 3.3 0.9 0.9 0.8 1.1 0.6 0.6 0.7 0.7 0.7 0.9 0.8 0.6
0
0.1 0.1 0.2 0.2
[1] 5h0b.a 1.4 0.4 1.0 1.0 1.0 1.4 3.3 0.9 0.9 0.8 1.1 0.6 0.6 0.7 0.7 0.7 0.9 0.8 0.6 0.1
0
0.2 0.3 0.2
[1] 5h0e.a 1.4 0.5 0.9 0.9 1.0 1.4 3.3 0.8 0.8 0.8 1.1 0.6 0.6 0.7 0.7 0.7 0.9 0.8 0.6 0.1 0.2
0
0.1 0.2
[1] 5h0g.a 1.4 0.6 0.9 0.9 1.0 1.5 3.2 0.9 0.9 0.8 1.1 0.6 0.6 0.7 0.7 0.7 0.9 0.8 0.6 0.2 0.3 0.1
0
0.3
[1] 5h0h.a 1.4 0.5 1.0 1.0 1.0 1.4 3.3 0.9 0.9 0.8 1.1 0.6 0.6 0.8 0.7 0.7 0.9 0.8 0.6 0.2 0.2 0.2 0.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1ad5.a
1qcf.a
2c0i.a
2c0o.a
2c0t.a
2hck.a
2hk5.a
3vry.a
3vrz.a
3vs0.b
3vs1.b
3vs2.a
3vs3.a
3vs4.a
3vs5.a
3vs6.a
3vs7.a
4lud.a
4lud.b
5h09.a
5h0b.a
5h0e.a
5h0g.a
5h0h.a
[1] 1ad5.a
0
1.3 1.8 1.8 1.8 0.9 3.8 1.5 1.8 1.7 1.8 1.5 1.6 1.5 1.4 1.4 1.8 1.4 1.4 1.5 1.5 1.4 1.4 1.4
[1] 1qcf.a 1.3
0
1.4 1.4 1.4 1.4 3.7 1.0 1.4 1.4 1.7 1.0 1.1 1.0 0.9 1.1 1.6 1.1 0.8 0.9 0.8 0.8 0.8 0.8
[1] 2c0i.a 1.8 1.4
0
0.4 0.3 1.8 3.4 1.1 0.6 0.9 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.0 1.1 1.5 1.5 1.4 1.4 1.5
[1] 2c0o.a 1.8 1.4 0.4
0
0.5 1.8 3.4 1.1 0.7 0.9 1.2 1.1 1.3 1.1 1.1 1.2 1.1 1.0 1.1 1.5 1.5 1.5 1.5 1.5
[1] 2c0t.a 1.8 1.4 0.3 0.5
0
1.9 3.4 1.1 0.6 0.9 1.1 1.1 1.4 1.1 1.2 1.2 1.2 1.0 1.1 1.5 1.5 1.4 1.4 1.5
[1] 2hck.a 0.9 1.4 1.8 1.8 1.9
0
4.0 1.5 1.8 1.7 1.8 1.5 1.6 1.6 1.4 1.4 1.8 1.5 1.4 1.5 1.5 1.5 1.5 1.5
[1] 2hk5.a 3.8 3.7 3.4 3.4 3.4 4.0
0
3.7 3.5 3.6 3.6 3.6 3.7 3.4 3.4 3.7 3.6 3.4 3.5 3.6 3.6 3.7 3.6 3.7
[1] 3vry.a 1.5 1.0 1.1 1.1 1.1 1.5 3.7
0
1.1 1.3 1.4 0.8 0.9 0.5 0.6 0.7 1.4 0.9 0.6 1.1 1.1 1.0 1.1 1.1
[1] 3vrz.a 1.8 1.4 0.6 0.7 0.6 1.8 3.5 1.1
0
0.9 1.1 1.2 1.4 1.1 1.2 1.2 1.3 1.1 1.1 1.5 1.5 1.4 1.5 1.5
[1] 3vs0.b 1.7 1.4 0.9 0.9 0.9 1.7 3.6 1.3 0.9
0
1.1 1.1 1.3 1.2 1.2 1.1 1.1 1.0 1.1 1.4 1.4 1.4 1.4 1.4
[1] 3vs1.b 1.8 1.7 1.2 1.2 1.1 1.8 3.6 1.4 1.1 1.1
0
1.4 1.7 1.5 1.4 1.5 1.5 1.0 1.4 1.7 1.7 1.7 1.7 1.7
[1] 3vs2.a 1.5 1.0 1.1 1.1 1.1 1.5 3.6 0.8 1.2 1.1 1.4
0
0.9 0.6 0.6 0.6 1.3 0.9 0.7 1.0 1.0 1.0 1.0 1.0
[1] 3vs3.a 1.6 1.1 1.3 1.3 1.4 1.6 3.7 0.9 1.4 1.3 1.7 0.9
0
0.7 0.9 0.8 1.4 1.0 0.7 1.2 1.2 1.1 1.2 1.2
[1] 3vs4.a 1.5 1.0 1.1 1.1 1.1 1.6 3.4 0.5 1.1 1.2 1.5 0.6 0.7
0
0.6 0.6 1.4 0.9 0.6 1.0 1.0 0.9 1.0 1.0
[1] 3vs5.a 1.4 0.9 1.2 1.1 1.2 1.4 3.4 0.6 1.2 1.2 1.4 0.6 0.9 0.6
0
0.4 1.3 0.8 0.6 1.0 1.0 0.9 0.9 0.9
[1] 3vs6.a 1.4 1.1 1.2 1.2 1.2 1.4 3.7 0.7 1.2 1.1 1.5 0.6 0.8 0.6 0.4
0
1.3 0.8 0.6 1.0 1.0 1.0 1.0 1.0
[1] 3vs7.a 1.8 1.6 1.2 1.1 1.2 1.8 3.6 1.4 1.3 1.1 1.5 1.3 1.4 1.4 1.3 1.3
0
1.0 1.3 1.5 1.5 1.5 1.5 1.6
[1] 4lud.a 1.4 1.1 1.0 1.0 1.0 1.5 3.4 0.9 1.1 1.0 1.0 0.9 1.0 0.9 0.8 0.8 1.0
0
0.7 1.1 1.1 1.0 1.1 1.1
[1] 4lud.b 1.4 0.8 1.1 1.1 1.1 1.4 3.5 0.6 1.1 1.1 1.4 0.7 0.7 0.6 0.6 0.6 1.3 0.7
0
0.8 0.8 0.7 0.8 0.8
[1] 5h09.a 1.5 0.9 1.5 1.5 1.5 1.5 3.6 1.1 1.5 1.4 1.7 1.0 1.2 1.0 1.0 1.0 1.5 1.1 0.8
0
0.1 0.3 0.5 0.3
[1] 5h0b.a 1.5 0.8 1.5 1.5 1.5 1.5 3.6 1.1 1.5 1.4 1.7 1.0 1.2 1.0 1.0 1.0 1.5 1.1 0.8 0.1
0
0.4 0.5 0.3
[1] 5h0e.a 1.4 0.8 1.4 1.5 1.4 1.5 3.7 1.0 1.4 1.4 1.7 1.0 1.1 0.9 0.9 1.0 1.5 1.0 0.7 0.3 0.4
0
0.4 0.3
[1] 5h0g.a 1.4 0.8 1.4 1.5 1.4 1.5 3.6 1.1 1.5 1.4 1.7 1.0 1.2 1.0 0.9 1.0 1.5 1.1 0.8 0.5 0.5 0.4
0
0.5
[1] 5h0h.a 1.4 0.8 1.5 1.5 1.5 1.5 3.7 1.1 1.5 1.4 1.7 1.0 1.2 1.0 0.9 1.0 1.6 1.1 0.8 0.3 0.3 0.3 0.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...