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GSTP_ONCVO_1_208

Glutathione S-transferase 2 [GST superfamily. Pi family]

Composition of the binding site

Protein chains homodimer [domain annotation]
A1 (GSTP_ONCVO):D: GST N-terminal (7, 8, 10, 13, 35, 38, 42, 49:51, 62, 63)
R: Glutathione binding (49, 50)
R: Glutathione binding (62, 63)
D: GST C-terminal (95, 106)
204
7, 8, 10, 13, 35, 38, 42, 49:51, 62, 63, 95, 106, 204
A2 (GSTP_ONCVO):D: GST C-terminal (96)96

Full PDB list

1tu7, 1tu8

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 A2
Y
7
F
8
I
1
0
L
1
3
F
3
8
K
4
2
Q
4
9
L
5
0
P
5
1
Q
6
2
S
6
3
R
9
5
Y
1
0
6
D
9
6
[1]1tu7.a gsh20 . . . . . . . . . . . . . .
[1]1tu8.c gtx26 . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 A2
Y
7
F
8
I
1
0
L
1
3
K
3
5
F
3
8
K
4
2
Q
4
9
L
5
0
P
5
1
Q
6
2
S
6
3
R
9
5
Y
1
0
6
G
2
0
4
D
9
6
[1]1tu7.a . . . . . . . . . . . . . . . .
[1]1tu8.c . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1tu7.a:gsh
1tu8.c:gtx
[1] 1tu7.a
0
0
[1] 1tu8.c 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1tu7.a
1tu8.c
[1] 1tu7.a
0
0
[1] 1tu8.c 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1tu7.a
1tu8.c
[1] 1tu7.a
0
0.2
[1] 1tu8.c 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1tu7.a
1tu8.c
[1] 1tu7.a
0
0.2
[1] 1tu8.c 0.2
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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