If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

GSTP1_MOUSE_2_210

Glutathione S-transferase P 1 [GST superfamily. Pi family]

Composition of the binding site

Protein chains homodimer [domain annotation]
A1 (GSTP1_MOUSE):D: GST N-terminal (8:11, 14, 36, 39, 45, 51:54, 65, 66)
R: Glutathione binding (52, 53)
R: Glutathione binding (65, 66)
D: GST C-terminal (109)
206
8:11, 14, 36, 39, 45, 51:54, 65, 66, 109, 206
A2 (GSTP1_MOUSE):D: GST C-terminal (99)99

Full PDB list

1bay, 1glp, 1glq, 1gsy, 1gti, 2glr, 2oa7, 2oac, 2oad, 3o76 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 A2
Y
8
F
9
V
1
1
R
1
4
I
3
6
W
3
9
K
4
5
Q
5
2
L
5
3
P
5
4
Q
6
5
S
6
6
Y
1
0
9
G
2
0
6
D
9
9
[1]1bay.a none . . . . - - - . . . . . . . .
[1]1glp.a gts23 . . . . . . . . . . . . . . .
[1]1gsy.b gsh19 . . . . . . . . . . . . . . .
[1]2glr.a gtx26 . . . . . . . . . . . . . . .
[1]3o76.b gtb29 . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 A2
Y
8
F
9
P
1
0
V
1
1
R
1
4
I
3
6
W
3
9
K
4
5
G
5
1
Q
5
2
L
5
3
P
5
4
Q
6
5
S
6
6
Y
1
0
9
G
2
0
6
D
9
9
[1]1bay.a . . . . . - - - - . . . . . . . .
[1]1glp.a . . . . . . . . . . . . . . . . .
[1]1gsy.b . . . . . . . . . . . . . . . . .
[1]2glr.a . . . . . . . . . . . . . . . . .
[1]3o76.b . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1bay.a is apo
1glp.a:gts
1gsy.b:gsh
2glr.a:gtx
3o76.b:gtb
[1] 1bay.a
-
0.1 0.1 0.1 0.1
[1] 1glp.a -
0
0 0 0.1
[1] 1gsy.b - 0.4
0
0.3 0.1
[1] 2glr.a - 0 0.1
0
0.1
[1] 3o76.b - 0.4 0.3 0.5
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1bay.a
1glp.a
1gsy.b
2glr.a
3o76.b
[1] 1bay.a
0
.01 .04 .02 .04
[1] 1glp.a .01
0
.02 .01 .04
[1] 1gsy.b .04 .02
0
.03 .06
[1] 2glr.a .02 .01 .03
0
.04
[1] 3o76.b .04 .04 .06 .04
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1bay.a
1glp.a
1gsy.b
2glr.a
3o76.b
[1] 1bay.a
0
0.5 0.7 0.5 0.6
[1] 1glp.a 0.5
0
0.5 0.1 0.5
[1] 1gsy.b 0.7 0.5
0
0.5 0.6
[1] 2glr.a 0.5 0.1 0.5
0
0.4
[1] 3o76.b 0.6 0.5 0.6 0.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1bay.a
1glp.a
1gsy.b
2glr.a
3o76.b
[1] 1bay.a
0
0.7 0.8 0.5 0.6
[1] 1glp.a 0.7
0
0.6 0.4 0.6
[1] 1gsy.b 0.8 0.6
0
0.7 0.8
[1] 2glr.a 0.5 0.4 0.7
0
0.4
[1] 3o76.b 0.6 0.6 0.8 0.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...