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GSTM2_CHICK_2_220

Glutathione S-transferase 2 [GST superfamily. Mu family]

Composition of the binding site

Protein chains homodimer [domain annotation]
A1 (GSTM2_CHICK):D: GST N-terminal (7, 8, 10, 12, 13, 41, 43, 46, 50, 59:61, 72, 73)
R: Glutathione binding (7, 8)
R: Glutathione binding (43, 46)
R: Glutathione binding (59, 60)
R: Glutathione binding (72, 73)
D: GST C-terminal (105, 108, 109, 112, 116, 166, 208)
209, 210
7, 8, 10, 12, 13, 41, 43, 46, 50, 59:61, 72, 73, 105, 108, 109, 112, 116, 166, 208:210
A2 (GSTM2_CHICK):D: GST C-terminal (106)106

Full PDB list

1c72, 1gsu

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 A2
Y
7
W
8
I
1
0
L
1
3
W
4
6
K
5
0
N
5
9
L
6
0
P
6
1
Q
7
2
S
7
3
M
1
0
5
R
1
0
8
Y
1
1
6
Q
1
6
6
F
2
0
9
W
2
1
0
D
1
0
6
[1]1c72.a epy34 . . . . . . . . . . . . . . . . . .
[1]1gsu.a gtx26 . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 A2
Y
7
W
8
I
1
0
G
1
2
L
1
3
F
4
1
P
4
3
W
4
6
K
5
0
N
5
9
L
6
0
P
6
1
Q
7
2
S
7
3
M
1
0
5
R
1
0
8
M
1
0
9
A
1
1
2
Y
1
1
6
Q
1
6
6
I
2
0
8
F
2
0
9
W
2
1
0
D
1
0
6
[1]1c72.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]1gsu.a . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1c72.a:epy
1gsu.a:gtx
[1] 1c72.a
0.2
0.5
[1] 1gsu.a 0.8
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1c72.a
1gsu.a
[1] 1c72.a
0
.04
[1] 1gsu.a .04
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1c72.a
1gsu.a
[1] 1c72.a
0
0.6
[1] 1gsu.a 0.6
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1c72.a
1gsu.a
[1] 1c72.a
0
1.4
[1] 1gsu.a 1.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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