GCR_HUMAN_509_777

Glucocorticoid receptor [Nuclear hormone receptor family. NR3 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (GCR_HUMAN):R: Interaction with CLOCK (540,541,559,560,563,564,566:568,570,571,574,600,601,603:605,607,608,611,623,629,634,639,642,643,646,667,732,733,735:737,739,740,747,749,752,753,756)
R: Steroid-binding (732,733,735:737,739,740,747,749,752,753,756)
R: Interaction with CRY1 (540,541,559,560,563,564,566:568,570,571,574,600,601,603:605,607,608,611,623,629,634,639,642,643,646,667)
540,541,559,560,563,564,566:568,570,571,574,600,601,603:605,607,608,611,623,629,634,639,642,643,646,667,732,733,735:737,739,740,747,749,752,753,756

Full PDB list

1m2z,1nhz,1p93,3bqd,3cld,3e7c,3h52,3k22,3k23,3mne,3mno,3mnp,4csj,4lsj,4mdd,4p6w,4p6x,4udc,4udd (redundant pocketome entry)

Contact map

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ligand
A1
E
5
4
0
P
5
4
1
I
5
5
9
M
5
6
0
L
5
6
3
N
5
6
4
L
5
6
6
G
5
6
7
G
5
6
8
Q
5
7
0
V
5
7
1
A
5
7
4
W
6
0
0
M
6
0
1
L
6
0
3
M
6
0
4
A
6
0
5
A
6
0
7
L
6
0
8
R
6
1
1
F
6
2
3
I
6
2
9
M
6
3
4
M
6
3
9
Q
6
4
2
C
6
4
3
M
6
4
6
K
6
6
7
L
7
3
2
L
7
3
3
Y
7
3
5
C
7
3
6
F
7
3
7
T
7
3
9
F
7
4
0
I
7
4
7
F
7
4
9
M
7
5
2
L
7
5
3
I
7
5
6
[1]4lsj.a lsj 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4csj.a nn7 33 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4udd.a cv7 34 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4mdd.a 29m 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3bqd.a day 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3k22.a jzs 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4p6w.a mof 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3e7c.a 866 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3cld.b gw6 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4p6x.c hcy 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3k23.a jzn 47 . . . . . . . . . . . . . . . . . . . . . . - . . . . . . . . . . . . . . . . .
[1]3h52.b 486 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1p93.b dex 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3mne.a dex 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3mnp.a dex 28 . . . . . . . . . . . . . . . . V . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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