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GCR_HUMAN_507_732

Glucocorticoid receptor [Nuclear hormone receptor family. NR3 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (GCR_HUMAN):R: Interaction with CLOCK (732, 733, 735:737, 739, 740, 747, 749, 750, 752:754, 756, 757)
D: NR LBD (540, 541, 559, 560, 563:568, 570, 571, 573, 574, 600, 601, 603:605, 607, 608, 611, 622, 623, 629, 634, 638, 639, 642, 643, 646, 667, 732, 733, 735:737, 739, 740, 747, 749, 750, 752:754, 756, 757)
R: Interaction with CRY1 (540, 541, 559, 560, 563:568, 570, 571, 573, 574, 600, 601, 603:605, 607, 608, 611, 622, 623, 629, 634, 638, 639, 642, 643, 646, 667)
540, 541, 559, 560, 563:568, 570, 571, 573, 574, 600, 601, 603:605, 607, 608, 611, 622, 623, 629, 634, 638, 639, 642, 643, 646, 667, 732, 733, 735:737, 739, 740, 747, 749, 750, 752:754, 756, 757

Full PDB list

1m2z, 1nhz, 1p93, 3bqd, 3cld, 3e7c, 3h52, 3k22, 3k23, 3mne, 3mno, 3mnp, 4csj, 4lsj, 4mdd, 4p6w, 4p6x, 4udc, 4udd, 5g3j, 5g5w, 5nfp, 5nft, 5uc1, 5uc3, 6el6, 6el7, 6el9 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
E
5
4
0
P
5
4
1
I
5
5
9
M
5
6
0
L
5
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3
N
5
6
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5
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6
G
5
6
7
G
5
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5
7
0
V
5
7
1
A
5
7
4
W
6
0
0
M
6
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1
L
6
0
3
M
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0
4
A
6
0
5
A
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0
7
L
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0
8
R
6
1
1
C
6
2
2
F
6
2
3
I
6
2
9
M
6
3
4
M
6
3
9
Q
6
4
2
C
6
4
3
M
6
4
6
K
6
6
7
L
7
3
2
L
7
3
3
Y
7
3
5
C
7
3
6
F
7
3
7
T
7
3
9
F
7
4
0
I
7
4
7
F
7
4
9
M
7
5
2
L
7
5
3
I
7
5
6
[1]1m2z.d dex28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1p93.c dex28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3bqd.a day36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3cld.b gw637 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3e7c.a 86637 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3h52.b 48632 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3k22.a jzs36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3k23.a jzn47 . . . . . . . . . . . . . . . . . . . . . . . - . . . . . . . . . . . . . . . . .
[1]3mno.a dex28 . . . . . . . . . . . . . . . . V . . . . . . . . . . . . . . . . . . . . . . . .
[1]4csj.a nn733 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4lsj.a lsj31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4mdd.a 29m36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4p6w.a mof35 . . . . . . . . . . . . . . . . . . . . Y . . . . . . . . . . . . . . . . . . . .
[1]4p6x.c hcy26 . . . . . . . . . . . . . . . . . . . . Y . . . . . . . . . . . . . . . . . . . .
[1]4udd.a cv734 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5g3j.a e7t32 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5g5w.a r8c33 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5nfp.a 8w531 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5nft.a 8w835 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5uc1.a 48632 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - - - - - - - - - -
[1]5uc3.a 48632 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . K . . . . . . - - - -
[1]6el6.a b9q34 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]6el7.a b9t29 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]6el9.a b9w36 . . . . . . . . . . M . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
E
5
4
0
P
5
4
1
I
5
5
9
M
5
6
0
L
5
6
3
N
5
6
4
M
5
6
5
L
5
6
6
G
5
6
7
G
5
6
8
Q
5
7
0
V
5
7
1
A
5
7
3
A
5
7
4
W
6
0
0
M
6
0
1
L
6
0
3
M
6
0
4
A
6
0
5
A
6
0
7
L
6
0
8
R
6
1
1
C
6
2
2
F
6
2
3
I
6
2
9
M
6
3
4
C
6
3
8
M
6
3
9
Q
6
4
2
C
6
4
3
M
6
4
6
K
6
6
7
L
7
3
2
L
7
3
3
Y
7
3
5
C
7
3
6
F
7
3
7
T
7
3
9
F
7
4
0
I
7
4
7
F
7
4
9
P
7
5
0
M
7
5
2
L
7
5
3
A
7
5
4
I
7
5
6
I
7
5
7
[1]1m2z.d . . . * . * . . . . * . . . . . . . . . . * . . . . . * * . * . . . . * . . . . * . . * . . .
[1]1p93.c . . . * . * . . . . * . . . . . . . . . . * . . . . D . * . * . . . . * . . . . * . . * . . .
[1]3bqd.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . * . . . . * . . . . * . . * . . .
[1]3cld.b . . . . . * . . . . * . . . . . . . . . . * . . . . G . . . * . . . . * . . . . * . . * . . .
[1]3e7c.a . . . . . . . . . . . . . . . . . . . . . . . . . . G . * . . . . . . * . . . . * . . * . . .
[1]3h52.b . . . * . . . . . . * . . . . . . . . . . * . . . . D * * . * . . . . . . . . . . . . * . . .
[1]3k22.a . . . . . . . . . . . . . . . . . . . . . . . . . . G . . . * . . . * * . . . . . . . * . . .
[1]3k23.a . . . * . . . . . . . . . . . . . . . . . . . . . - G . . . . . . . * * . . . . . . . * . . .
[1]3mno.a . . . * . * . . . . * . . . . . . . V . . * . . . . . . * . * . . . . * . . . . * . . * . . .
[1]4csj.a . . . * . . . . . . . M . . . . . . . . . . . . . . D . * . * . . . . * . . . . * . . * . . .
[1]4lsj.a . . . . . . . . . . . . . . . . . * . . . * . . . . G * . . . . . . * * . . . . * . . * . . .
[1]4mdd.a . . . . . . . . . . * . . . . . . * . . . * . . . . D . . . * . . . * * . . . . . . . . . . .
[1]4p6w.a . . . . . . . . . . . . . . . . . . . . . * Y . . . . . . . * . . . . * . . . . * . . * . . .
[1]4p6x.c . . . . . * . . . . * . . . . . . * . . . * Y . . . . . * . * . . . . * . . . . * . . * . . .
[1]4udd.a . . . . . . . . . . * M . . . . . . . . . * . . . . D . . . * . . . * * . . . . * . . * . . .
[1]5g3j.a . . . * . . . . . . . M . . . . . * . . . * . . . . D . * . * . . . . * . . . . * . . * . . .
[1]5g5w.a . . . * . * . . . . . M . . . . . . . . . . . . . . D . * . * . . . . * . . . . * . . * . . .
[1]5nfp.a . . . * . . . . . . * M . . . . . . . . . * . . . . D . * . * . . . . * . . . . * . . * . . .
[1]5nft.a . . . * . . . . . . . M . . . . . . . . . . . . . . D . * . * . . . . * . . . . * . . * . . .
[1]5uc1.a . . . . . . . . . . * . . . . . . . . . . * . . . . Y . . . * . - - - - - - - - - - - - - - -
[1]5uc3.a . . . * . . . . . . * . . . . . . * . . . * . . . . . . * . * . . K . * . * . . - - - - - - -
[1]6el6.a . . . * . . . . . . . M . . . . . . . . . . . . . . D . * . * . . . . * . . . . * . . * . . .
[1]6el7.a . . . . . . . . . . . M . . . . . . . . . * . . . . D . * . * . . . . * . . . . * . . * . . .
[1]6el9.a . . . * . . . . . . . M . . . . . . . . . . . . . . D . * . * . . . . * . . . . * . . * . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1m2z.d:dex
1p93.c:dex
3bqd.a:day
3cld.b:gw6
3e7c.a:866
3h52.b:486
3k22.a:jzs
3k23.a:jzn
3mno.a:dex
4csj.a:nn7
4lsj.a:lsj
4mdd.a:29m
4p6w.a:mof
4p6x.c:hcy
4udd.a:cv7
5g3j.a:e7t
5g5w.a:r8c
5nfp.a:8w5
5nft.a:8w8
5uc1.a:486
5uc3.a:486
6el6.a:b9q
6el7.a:b9t
6el9.a:b9w
[1] 1m2z.d
0
0.1 2.7 1.5 4.7 3.7 2.9 3.7 0 3.2 1.7 5.8 1.8 0 1.2 1.2 3.3 0.2 3.2 3.9 3.1 2.9 0.8 3.1
[1] 1p93.c 0
0.2
3.6 1.6 5.2 3.1 3.3 4.0 0.1 3.1 1.6 4.5 1.3 0 1.5 1.6 3.3 0.6 3.7 3.2 2.8 3.4 1.0 3.6
[1] 3bqd.a 0 0.1
0
0.8 2.0 2.6 0.8 1.6 0 0.3 1.5 4.3 1.5 0.1 0.9 0.5 0.5 0.2 0.6 3.0 2.6 0.4 0.2 0.6
[1] 3cld.b 0 0.2 3.1
0
3.5 3.2 2.9 3.7 0 2.9 1.2 3.4 0.5 0.1 0.3 1.0 2.7 0 2.6 3.2 2.5 2.6 0.5 3.6
[1] 3e7c.a 1.9 2.1 2.0 2.0
0.1
3.0 0.8 1.6 1.8 0.6 0.9 2.8 2.5 0.6 1.0 0.5 0.2 1.1 0.3 3.6 3.7 0.1 0.4 1.1
[1] 3h52.b 0.1 0.8 3.8 1.4 5.8
0.1
2.7 2.9 0.6 3.5 1.4 3.7 1.5 0.4 1.9 2.1 3.6 0.8 3.8 0.4 1.7 3.5 1.5 4.6
[1] 3k22.a 0.7 1.6 1.3 1.1 2.5 2.3
0
0.7 0.7 0.1 1.0 2.9 0.9 0.9 0.9 0.7 0.6 0.7 0.7 2.6 2.5 1.3 1.1 1.4
[1] 3k23.a 0.4 0.8 0.7 0.9 1.7 2.0 0
0.3
0.3 0.1 0.8 3.2 0.6 0.4 0.5 0.4 0.1 0.3 0.1 2.1 1.8 0.5 0.5 0.6
[1] 3mno.a 0.1 0.3 3.4 2.0 4.8 4.2 3.4 3.9
0
3.6 2.0 6.6 2.3 0.1 2.1 2.3 3.9 1.0 3.4 3.9 3.8 3.6 1.6 4.4
[1] 4csj.a 0.3 0.5 0.7 1.0 2.1 3.0 0.4 1.2 0.4
0
1.4 5.2 1.7 0.5 1.0 0.3 0 0.5 0 3.3 2.7 0.1 0.3 0.2
[1] 4lsj.a 1.0 1.6 3.6 3.2 5.4 3.1 1.9 2.8 0.9 2.9
0
3.9 2.6 0.7 2.4 1.2 2.6 2.2 3.4 3.3 3.5 3.7 1.8 3.6
[1] 4mdd.a 2.6 2.0 4.3 2.3 4.6 1.3 2.8 3.1 2.8 3.5 2.4
0
2.2 2.1 2.0 2.3 4.1 1.9 4.3 1.6 1.3 4.2 2.4 4.4
[1] 4p6w.a 0 0.2 2.8 0.1 2.9 2.7 2.4 3.3 0 2.5 1.0 3.4
0
0 0.1 1.1 2.5 0 2.4 3.2 2.6 2.3 0.5 3.3
[1] 4p6x.c 0 0.4 3.4 1.6 4.9 4.1 3.2 4.2 0 2.5 1.8 4.7 1.5
0
1.2 1.7 3.3 0.5 3.2 3.3 3.7 3.3 0.7 3.8
[1] 4udd.a 0 0.6 3.5 0.7 5.2 2.8 2.8 3.8 0 2.8 1.0 4.1 0.3 0.2
0
1.1 3.0 0 2.9 3.3 2.8 2.9 0.7 3.8
[1] 5g3j.a 0.3 0.8 2.8 1.0 4.0 2.7 1.8 2.4 0.6 2.3 1.3 5.0 1.3 0.6 0.9
0
2.4 0.5 2.2 3.2 2.7 2.3 0.3 3.2
[1] 5g5w.a 2.2 2.1 2.2 2.1 0.9 3.9 1.0 2.5 2.3 0.4 1.0 4.8 2.9 1.2 1.9 0.6
0
1.3 0 4.3 3.8 0.2 0.6 0.3
[1] 5nfp.a 0 0.2 3.5 0.5 4.2 2.9 3.4 4.0 0 2.9 1.5 5.1 0.6 0.1 0.4 1.1 3.1
0
3.0 3.4 2.7 2.8 0.6 3.6
[1] 5nft.a 2.6 2.3 2.6 2.5 0.8 3.8 1.0 2.4 2.0 0.5 1.3 5.5 3.2 1.2 2.0 0.6 0 1.6
0
4.6 3.8 0.1 0.6 0.3
[1] 5uc1.a 0.2 0.3 3.1 0.5 4.0 0 2.9 2.7 0.5 2.9 1.4 1.0 0.8 0.4 0.7 1.4 3.5 0.5 3.3
0.1
0.3 3.4 1.2 3.9
[1] 5uc3.a 1.6 1.8 6.0 3.8 6.2 0.1 2.5 3.3 2.2 3.2 3.2 4.0 3.6 1.8 3.6 2.6 4.1 2.5 4.3 0.1
0
3.4 2.2 5.0
[1] 6el6.a 2.1 2.1 2.1 2.1 1.0 4.0 0.7 2.2 2.0 0.3 1.0 4.6 2.6 1.0 1.7 0.4 0 1.2 0 4.1 3.5
0
0.5 0.2
[1] 6el7.a 1.7 1.5 4.2 1.6 2.7 3.8 2.0 2.7 1.6 2.4 1.4 4.4 2.1 0.5 1.1 0.2 2.3 0.7 2.2 4.1 3.6 2.2
0
2.9
[1] 6el9.a 0 0.1 0.8 1.2 2.2 3.0 0.4 2.0 0 0.1 1.4 5.3 1.5 0 0.8 0.6 0.2 0.1 0.1 3.7 3.0 0.2 0.4
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1m2z.d
1p93.c
3bqd.a
3cld.b
3e7c.a
3h52.b
3k22.a
3k23.a
3mno.a
4csj.a
4lsj.a
4mdd.a
4p6w.a
4p6x.c
4udd.a
5g3j.a
5g5w.a
5nfp.a
5nft.a
5uc1.a
5uc3.a
6el6.a
6el7.a
6el9.a
[1] 1m2z.d
0
.07 .13 .12 .17 .19 .27 .25 .11 .13 .24 .27 .12 .06 .16 .09 .16 .06 .17 .23 .20 .14 .08 .15
[1] 1p93.c .07
0
.13 .10 .15 .16 .24 .23 .11 .14 .23 .24 .10 .06 .15 .10 .16 .09 .17 .19 .20 .14 .09 .14
[1] 3bqd.a .13 .13
0
.17 .09 .24 .18 .16 .17 .06 .26 .29 .16 .15 .21 .11 .08 .14 .10 .27 .25 .06 .12 .08
[1] 3cld.b .12 .10 .17
0
.18 .17 .19 .19 .12 .17 .18 .18 .03 .10 .10 .12 .18 .10 .19 .19 .21 .16 .10 .19
[1] 3e7c.a .17 .15 .09 .18
0
.19 .15 .14 .19 .10 .22 .26 .16 .17 .23 .15 .10 .19 .12 .23 .24 .08 .16 .12
[1] 3h52.b .19 .16 .24 .17 .19
0
.24 .21 .20 .25 .21 .19 .17 .19 .21 .19 .23 .20 .26 .12 .14 .24 .17 .26
[1] 3k22.a .27 .24 .18 .19 .15 .24
0
.09 .27 .19 .15 .20 .18 .26 .16 .22 .19 .25 .22 .27 .27 .19 .23 .21
[1] 3k23.a .25 .23 .16 .19 .14 .21 .09
0
.27 .18 .19 .20 .17 .25 .18 .22 .16 .24 .19 .27 .22 .17 .23 .19
[1] 3mno.a .11 .11 .17 .12 .19 .20 .27 .27
0
.17 .24 .29 .15 .10 .18 .11 .20 .10 .20 .22 .20 .19 .12 .18
[1] 4csj.a .13 .14 .06 .17 .10 .25 .19 .18 .17
0
.28 .31 .17 .16 .22 .09 .05 .13 .05 .28 .27 .04 .10 .04
[1] 4lsj.a .24 .23 .26 .18 .22 .21 .15 .19 .24 .28
0
.22 .19 .23 .14 .21 .27 .23 .30 .26 .24 .28 .21 .30
[1] 4mdd.a .27 .24 .29 .18 .26 .19 .20 .20 .29 .31 .22
0
.17 .27 .21 .26 .30 .26 .32 .14 .14 .30 .27 .33
[1] 4p6w.a .12 .10 .16 .03 .16 .17 .18 .17 .15 .17 .19 .17
0
.11 .09 .14 .18 .11 .19 .20 .21 .16 .12 .18
[1] 4p6x.c .06 .06 .15 .10 .17 .19 .26 .25 .10 .16 .23 .27 .11
0
.16 .12 .18 .08 .20 .23 .21 .15 .10 .17
[1] 4udd.a .16 .15 .21 .10 .23 .21 .16 .18 .18 .22 .14 .21 .09 .16
0
.16 .22 .13 .24 .26 .22 .21 .15 .24
[1] 5g3j.a .09 .10 .11 .12 .15 .19 .22 .22 .11 .09 .21 .26 .14 .12 .16
0
.13 .07 .13 .21 .21 .12 .06 .12
[1] 5g5w.a .16 .16 .08 .18 .10 .23 .19 .16 .20 .05 .27 .30 .18 .18 .22 .13
0
.17 .04 .29 .28 .03 .11 .07
[1] 5nfp.a .06 .09 .14 .10 .19 .20 .25 .24 .10 .13 .23 .26 .11 .08 .13 .07 .17
0
.18 .21 .20 .16 .07 .16
[1] 5nft.a .17 .17 .10 .19 .12 .26 .22 .19 .20 .05 .30 .32 .19 .20 .24 .13 .04 .18
0
.31 .31 .05 .13 .05
[1] 5uc1.a .23 .19 .27 .19 .23 .12 .27 .27 .22 .28 .26 .14 .20 .23 .26 .21 .29 .21 .31
0
.14 .28 .20 .29
[1] 5uc3.a .20 .20 .25 .21 .24 .14 .27 .22 .20 .27 .24 .14 .21 .21 .22 .21 .28 .20 .31 .14
0
.28 .21 .29
[1] 6el6.a .14 .14 .06 .16 .08 .24 .19 .17 .19 .04 .28 .30 .16 .15 .21 .12 .03 .16 .05 .28 .28
0
.10 .05
[1] 6el7.a .08 .09 .12 .10 .16 .17 .23 .23 .12 .10 .21 .27 .12 .10 .15 .06 .11 .07 .13 .20 .21 .10
0
.12
[1] 6el9.a .15 .14 .08 .19 .12 .26 .21 .19 .18 .04 .30 .33 .18 .17 .24 .12 .07 .16 .05 .29 .29 .05 .12
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1m2z.d
1p93.c
3bqd.a
3cld.b
3e7c.a
3h52.b
3k22.a
3k23.a
3mno.a
4csj.a
4lsj.a
4mdd.a
4p6w.a
4p6x.c
4udd.a
5g3j.a
5g5w.a
5nfp.a
5nft.a
5uc1.a
5uc3.a
6el6.a
6el7.a
6el9.a
[1] 1m2z.d
0
0.6 0.7 0.6 0.6 8.9 0.7 1.1 0.8 0.7 9.4 11 0.5 0.5 0.9 0.7 0.6 0.6 0.7 1.0 1.6 0.6 0.6 0.6
[1] 1p93.c 0.6
0
0.8 0.7 0.7 8.9 0.9 1.2 1.0 0.9 9.5 11 0.6 0.6 1.0 0.9 0.8 0.8 0.9 0.9 1.6 0.8 0.8 0.9
[1] 3bqd.a 0.7 0.8
0
0.6 0.6 9.0 0.6 1.0 0.6 0.6 9.5 12 0.7 0.6 1.0 0.6 0.6 0.6 0.6 0.9 1.6 0.6 0.7 0.6
[1] 3cld.b 0.6 0.7 0.6
0
0.6 8.9 0.5 1.0 0.7 0.5 9.5 11 0.5 0.5 0.8 0.5 0.6 0.5 0.6 1.0 1.6 0.6 0.5 0.5
[1] 3e7c.a 0.6 0.7 0.6 0.6
0
8.9 0.6 0.8 0.8 0.6 9.4 11 0.5 0.5 1.0 0.7 0.6 0.7 0.6 1.0 1.6 0.6 0.6 0.7
[1] 3h52.b 8.9 8.9 9.0 8.9 8.9
0
8.9 9.0 9.0 8.9 3.0 4.9 8.9 8.9 9.0 8.9 8.9 8.9 8.9 10 9.5 8.9 8.9 8.9
[1] 3k22.a 0.7 0.9 0.6 0.5 0.6 8.9
0
0.8 0.7 0.6 9.4 11 0.6 0.7 0.9 0.6 0.7 0.6 0.7 0.9 1.6 0.7 0.7 0.6
[1] 3k23.a 1.1 1.2 1.0 1.0 0.8 9.0 0.8
0
0.9 0.9 9.4 12 0.9 1.0 1.3 0.9 1.0 1.0 1.0 1.4 1.7 1.0 1.0 1.0
[1] 3mno.a 0.8 1.0 0.6 0.7 0.8 9.0 0.7 0.9
0
0.7 9.5 12 0.7 0.7 1.1 0.7 0.7 0.7 0.8 1.1 1.7 0.7 0.8 0.7
[1] 4csj.a 0.7 0.9 0.6 0.5 0.6 8.9 0.6 0.9 0.7
0
9.4 12 0.6 0.7 0.8 0.3 0.3 0.3 0.4 0.9 1.6 0.3 0.4 0.3
[1] 4lsj.a 9.4 9.5 9.5 9.5 9.4 3.0 9.4 9.4 9.5 9.4
0
5.7 9.4 9.5 9.5 9.5 9.4 9.4 9.4 12 10 9.4 9.4 9.5
[1] 4mdd.a 11 11 12 11 11 4.9 11 12 12 12 5.7
0
11 11 12 12 11 12 11 12 11 12 12 12
[1] 4p6w.a 0.5 0.6 0.7 0.5 0.5 8.9 0.6 0.9 0.7 0.6 9.4 11
0
0.5 0.9 0.7 0.6 0.6 0.6 1.1 1.6 0.6 0.5 0.6
[1] 4p6x.c 0.5 0.6 0.6 0.5 0.5 8.9 0.7 1.0 0.7 0.7 9.5 11 0.5
0
1.0 0.7 0.6 0.6 0.7 1.0 1.6 0.6 0.6 0.7
[1] 4udd.a 0.9 1.0 1.0 0.8 1.0 9.0 0.9 1.3 1.1 0.8 9.5 12 0.9 1.0
0
0.8 1.0 0.6 0.9 1.3 1.7 0.9 0.9 0.8
[1] 5g3j.a 0.7 0.9 0.6 0.5 0.7 8.9 0.6 0.9 0.7 0.3 9.5 12 0.7 0.7 0.8
0
0.5 0.3 0.5 0.9 1.6 0.4 0.5 0.4
[1] 5g5w.a 0.6 0.8 0.6 0.6 0.6 8.9 0.7 1.0 0.7 0.3 9.4 11 0.6 0.6 1.0 0.5
0
0.5 0.2 1.0 1.6 0.2 0.3 0.3
[1] 5nfp.a 0.6 0.8 0.6 0.5 0.7 8.9 0.6 1.0 0.7 0.3 9.4 12 0.6 0.6 0.6 0.3 0.5
0
0.5 1.0 1.6 0.4 0.4 0.3
[1] 5nft.a 0.7 0.9 0.6 0.6 0.6 8.9 0.7 1.0 0.8 0.4 9.4 11 0.6 0.7 0.9 0.5 0.2 0.5
0
0.9 1.7 0.3 0.3 0.3
[1] 5uc1.a 1.0 0.9 0.9 1.0 1.0 10 0.9 1.4 1.1 0.9 12 12 1.1 1.0 1.3 0.9 1.0 1.0 0.9
0
0.7 1.0 1.0 0.9
[1] 5uc3.a 1.6 1.6 1.6 1.6 1.6 9.5 1.6 1.7 1.7 1.6 10 11 1.6 1.6 1.7 1.6 1.6 1.6 1.7 0.7
0
1.6 1.6 1.6
[1] 6el6.a 0.6 0.8 0.6 0.6 0.6 8.9 0.7 1.0 0.7 0.3 9.4 12 0.6 0.6 0.9 0.4 0.2 0.4 0.3 1.0 1.6
0
0.3 0.3
[1] 6el7.a 0.6 0.8 0.7 0.5 0.6 8.9 0.7 1.0 0.8 0.4 9.4 12 0.5 0.6 0.9 0.5 0.3 0.4 0.3 1.0 1.6 0.3
0
0.3
[1] 6el9.a 0.6 0.9 0.6 0.5 0.7 8.9 0.6 1.0 0.7 0.3 9.5 12 0.6 0.7 0.8 0.4 0.3 0.3 0.3 0.9 1.6 0.3 0.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1m2z.d
1p93.c
3bqd.a
3cld.b
3e7c.a
3h52.b
3k22.a
3k23.a
3mno.a
4csj.a
4lsj.a
4mdd.a
4p6w.a
4p6x.c
4udd.a
5g3j.a
5g5w.a
5nfp.a
5nft.a
5uc1.a
5uc3.a
6el6.a
6el7.a
6el9.a
[1] 1m2z.d
0
0.9 1.0 0.9 1.1 9.3 1.2 1.4 0.9 1.0 9.6 12 0.8 0.8 1.1 0.9 1.1 0.8 1.1 1.2 2.2 1.1 1.0 0.9
[1] 1p93.c 0.9
0
1.3 1.2 1.3 9.3 1.5 1.6 1.3 1.3 9.7 12 1.1 1.0 1.4 1.3 1.4 1.1 1.4 1.3 2.0 1.4 1.3 1.2
[1] 3bqd.a 1.0 1.3
0
1.2 1.1 9.4 1.2 1.3 0.8 0.9 9.7 12 1.1 0.9 1.4 1.0 1.2 1.0 1.2 1.3 2.1 1.2 1.2 0.9
[1] 3cld.b 0.9 1.2 1.2
0
1.0 9.4 0.9 1.2 1.1 1.2 9.6 12 0.8 1.1 1.0 1.0 1.0 0.9 1.0 1.4 2.3 1.0 0.9 1.1
[1] 3e7c.a 1.1 1.3 1.1 1.0
0
9.4 0.9 1.1 1.2 1.1 9.7 12 1.0 1.1 1.4 1.2 0.8 1.2 0.9 1.6 2.2 0.9 1.0 1.1
[1] 3h52.b 9.3 9.3 9.4 9.4 9.4
0
9.4 9.5 9.4 9.5 3.5 5.3 9.3 9.4 9.4 9.5 9.5 9.5 9.5 11 10 9.5 9.4 9.5
[1] 3k22.a 1.2 1.5 1.2 0.9 0.9 9.4
0
0.9 1.3 1.2 9.7 12 1.1 1.3 1.2 1.2 1.1 1.2 1.1 1.4 2.0 1.1 1.2 1.2
[1] 3k23.a 1.4 1.6 1.3 1.2 1.1 9.5 0.9
0
1.2 1.3 9.7 12 1.1 1.4 1.4 1.2 1.2 1.3 1.2 1.5 2.3 1.2 1.3 1.3
[1] 3mno.a 0.9 1.3 0.8 1.1 1.2 9.4 1.3 1.2
0
1.1 9.7 12 1.0 0.9 1.3 0.9 1.3 0.9 1.3 1.4 2.2 1.3 1.2 1.1
[1] 4csj.a 1.0 1.3 0.9 1.2 1.1 9.5 1.2 1.3 1.1
0
9.8 12 1.2 1.0 1.3 0.6 1.0 0.7 1.0 1.2 2.1 1.0 1.0 0.6
[1] 4lsj.a 9.6 9.7 9.7 9.6 9.7 3.5 9.7 9.7 9.7 9.8
0
5.9 9.6 9.7 9.7 9.8 9.7 9.8 9.7 12 11 9.8 9.7 9.8
[1] 4mdd.a 12 12 12 12 12 5.3 12 12 12 12 5.9
0
12 12 12 12 12 12 12 13 11 12 12 12
[1] 4p6w.a 0.8 1.1 1.1 0.8 1.0 9.3 1.1 1.1 1.0 1.2 9.6 12
0
1.0 1.1 1.1 1.1 1.0 1.1 1.4 2.2 1.1 0.9 1.1
[1] 4p6x.c 0.8 1.0 0.9 1.1 1.1 9.4 1.3 1.4 0.9 1.0 9.7 12 1.0
0
1.4 1.0 1.3 0.8 1.3 1.3 2.2 1.3 1.1 1.1
[1] 4udd.a 1.1 1.4 1.4 1.0 1.4 9.4 1.2 1.4 1.3 1.3 9.7 12 1.1 1.4
0
1.1 1.5 1.0 1.4 1.5 2.3 1.4 1.3 1.1
[1] 5g3j.a 0.9 1.3 1.0 1.0 1.2 9.5 1.2 1.2 0.9 0.6 9.8 12 1.1 1.0 1.1
0
1.0 0.6 1.0 1.2 2.0 1.0 0.9 0.7
[1] 5g5w.a 1.1 1.4 1.2 1.0 0.8 9.5 1.1 1.2 1.3 1.0 9.7 12 1.1 1.3 1.5 1.0
0
1.1 0.3 1.5 2.3 0.5 0.6 0.9
[1] 5nfp.a 0.8 1.1 1.0 0.9 1.2 9.5 1.2 1.3 0.9 0.7 9.8 12 1.0 0.8 1.0 0.6 1.1
0
1.1 1.2 2.0 1.1 0.9 0.7
[1] 5nft.a 1.1 1.4 1.2 1.0 0.9 9.5 1.1 1.2 1.3 1.0 9.7 12 1.1 1.3 1.4 1.0 0.3 1.1
0
1.5 2.3 0.5 0.6 0.8
[1] 5uc1.a 1.2 1.3 1.3 1.4 1.6 11 1.4 1.5 1.4 1.2 12 13 1.4 1.3 1.5 1.2 1.5 1.2 1.5
0
1.0 1.5 1.4 1.2
[1] 5uc3.a 2.2 2.0 2.1 2.3 2.2 10 2.0 2.3 2.2 2.1 11 11 2.2 2.2 2.3 2.0 2.3 2.0 2.3 1.0
0
2.3 2.3 2.2
[1] 6el6.a 1.1 1.4 1.2 1.0 0.9 9.5 1.1 1.2 1.3 1.0 9.8 12 1.1 1.3 1.4 1.0 0.5 1.1 0.5 1.5 2.3
0
0.7 0.9
[1] 6el7.a 1.0 1.3 1.2 0.9 1.0 9.4 1.2 1.3 1.2 1.0 9.7 12 0.9 1.1 1.3 0.9 0.6 0.9 0.6 1.4 2.3 0.7
0
0.9
[1] 6el9.a 0.9 1.2 0.9 1.1 1.1 9.5 1.2 1.3 1.1 0.6 9.8 12 1.1 1.1 1.1 0.7 0.9 0.7 0.8 1.2 2.2 0.9 0.9
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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