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FUS3_YEAST_1_353

Mitogen-activated protein kinase FUS3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (FUS3_YEAST):D: Protein kinase (19, 24, 25, 27, 40, 42, 55, 72, 93:97, 99, 102, 141, 142, 144, 154, 155)19, 24, 25, 27, 40, 42, 55, 72, 93:97, 99, 102, 141, 142, 144, 154, 155
Metals (Me):Mg

Full PDB list

2b9f, 2b9h, 2b9i, 2b9j, 2f49, 2f9g, 2fa2 (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1 Me
L
1
9
Y
2
4
V
2
7
A
4
0
K
4
2
R
5
5
I
7
2
Q
9
3
E
9
4
L
9
5
M
9
6
D
9
9
S
1
4
1
N
1
4
2
L
1
4
4
C
1
5
4
D
1
5
5
[1]2b9j.a adp27 . . . . . . . . . . . . . . . . . Mg
[1]2fa2.b none . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 Me
L
1
9
Y
2
4
G
2
5
V
2
7
A
4
0
K
4
2
R
5
5
I
7
2
Q
9
3
E
9
4
L
9
5
M
9
6
Q
9
7
D
9
9
R
1
0
2
S
1
4
1
N
1
4
2
L
1
4
4
C
1
5
4
D
1
5
5
[1]2b9j.a . . . . . . . . . . . . . . . . . . . . Mg
[1]2fa2.b . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2b9j.a:adp
2fa2.b is apo
[1] 2b9j.a
0
-
[1] 2fa2.b 2.1
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2b9j.a
2fa2.b
[1] 2b9j.a
0
.11
[1] 2fa2.b .11
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2b9j.a
2fa2.b
[1] 2b9j.a
0
1.6
[1] 2fa2.b 1.6
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2b9j.a
2fa2.b
[1] 2b9j.a
0
2.5
[1] 2fa2.b 2.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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