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FLT3_HUMAN_600_952

Receptor-type tyrosine-protein kinase FLT3 [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (FLT3_HUMAN):D: Protein kinase (614, 616, 624, 642, 644, 661, 664, 665, 668, 674, 675, 691, 693:697, 802, 809, 818, 827:830)
574, 576
574, 576, 614, 616, 624, 642, 644, 661, 664, 665, 668, 674, 675, 691, 693:697, 802, 809, 818, 827:830

Full PDB list

1rjb, 4rt7, 4xuf (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
6
1
6
V
6
2
4
A
6
4
2
K
6
4
4
E
6
6
1
M
6
6
5
L
6
6
8
V
6
7
5
F
6
9
1
Y
6
9
3
C
6
9
4
C
6
9
5
G
6
9
7
H
8
0
9
L
8
1
8
C
8
2
8
D
8
2
9
F
8
3
0
[1]1rjb.a none . . . . . . . . . . . . . . . . . .
[1]4rt7.a p3040 . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
S
5
7
4
L
5
7
6
K
6
1
4
L
6
1
6
V
6
2
4
A
6
4
2
K
6
4
4
E
6
6
1
M
6
6
4
M
6
6
5
L
6
6
8
I
6
7
4
V
6
7
5
F
6
9
1
Y
6
9
3
C
6
9
4
C
6
9
5
Y
6
9
6
G
6
9
7
L
8
0
2
H
8
0
9
L
8
1
8
I
8
2
7
C
8
2
8
D
8
2
9
F
8
3
0
[1]1rjb.a . * . . . . . . . . . . . . . . . . . . . . . . . *
[1]4rt7.a - - . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1rjb.a is apo
4rt7.a:p30
[1] 1rjb.a
-
5.3
[1] 4rt7.a -
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1rjb.a
4rt7.a
[1] 1rjb.a
0
.20
[1] 4rt7.a .20
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1rjb.a
4rt7.a
[1] 1rjb.a
0
0.6
[1] 4rt7.a 0.6
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1rjb.a
4rt7.a
[1] 1rjb.a
0
0.9
[1] 4rt7.a 0.9
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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