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FGFR4_HUMAN_444_753

Fibroblast growth factor receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (FGFR4_HUMAN):D: Protein kinase (473:478, 481, 483, 501:503, 517, 520, 523, 524, 527, 533, 534, 548, 550:557, 560, 603, 608:611, 616, 619, 628:635, 641:644, 647, 648)473:478, 481, 483, 501:503, 517, 520, 523, 524, 527, 533, 534, 548, 550:557, 560, 603, 608:611, 616, 619, 628:635, 641:644, 647, 648

Full PDB list

4qq5, 4qqc, 4qqj, 4qqt, 4qrc, 4r6v, 4tye, 4tyg, 4tyi, 4tyj, 4uxq, 4xcu, 5jkg (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
4
7
3
G
4
7
4
E
4
7
5
G
4
7
6
C
4
7
7
F
4
7
8
V
4
8
1
A
5
0
1
V
5
0
2
K
5
0
3
E
5
2
0
V
5
2
3
M
5
2
4
I
5
2
7
I
5
3
3
I
5
3
4
V
5
4
8
V
5
5
0
E
5
5
1
C
5
5
2
A
5
5
3
A
5
5
4
G
5
5
6
N
5
5
7
E
5
6
0
C
6
0
8
I
6
0
9
H
6
1
0
R
6
1
1
R
6
1
6
L
6
1
9
I
6
2
8
A
6
2
9
D
6
3
0
F
6
3
1
L
6
3
3
[1]4qq5.a 37o47 . . . . * . . . . . . . . . . . . L . . . . . . . . . . . . . . . . . .
[1]4qqc.a 37o47 . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qqj.a none . . . - - - . . . . . . . . . . . L . . . . . . . . . . . . . . . . . .
[1]4r6v.a fi348 . . . . * . . . . . . . . . . . . L . . . . . . . . . . . . . . . . . .
[1]4tyi.a 38o29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4tyj.a 0li39 . . . . - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4uxq.a 0li39 . . . . A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4xcu.a 40m35 . . . - - - . . . . . . . . . . . . . * . . . . . . . . . . . . . . . .
[1]5jkg.a 6lf30 . . . . A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4tyg.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
4
7
3
G
4
7
4
E
4
7
5
G
4
7
6
C
4
7
7
F
4
7
8
V
4
8
1
R
4
8
3
A
5
0
1
V
5
0
2
K
5
0
3
L
5
1
7
E
5
2
0
V
5
2
3
M
5
2
4
I
5
2
7
I
5
3
3
I
5
3
4
V
5
4
8
V
5
5
0
E
5
5
1
C
5
5
2
A
5
5
3
A
5
5
4
K
5
5
5
G
5
5
6
N
5
5
7
E
5
6
0
L
6
0
3
C
6
0
8
I
6
0
9
H
6
1
0
R
6
1
1
R
6
1
6
L
6
1
9
I
6
2
8
A
6
2
9
D
6
3
0
F
6
3
1
G
6
3
2
L
6
3
3
A
6
3
4
R
6
3
5
D
6
4
1
Y
6
4
2
Y
6
4
3
K
6
4
4
S
6
4
7
N
6
4
8
[1]4qq5.a . . . . * . . . . . . . . . . . . . . L . * . . . . . . . . . . . . . . . . * . * . - - - - - - -
[1]4qqc.a . . * . * . . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . * * . * - - - - - - - -
[1]4qqj.a . . . - - - . . . . . . . . . . . . . L . * . . . . . . . . . . . * . . . . * * . . . . . . . . .
[1]4r6v.a . . . . * . . . . . . . . . . . . . . L . * . . . . . . . . . . . . . . . * * . * . - - - - - - -
[1]4tyi.a . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . * * . . . - - - - - -
[1]4tyj.a . . . . - - . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . * . . . . - - - - - -
[1]4uxq.a . . . . A . . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . * . . . . . . . . . .
[1]4xcu.a . . . - - - . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . * * . * . . . . . . .
[1]5jkg.a . . * . A . . . . . * . . . . . . . . . . * . . . . . . . . . . . . . . . * * * . - - - - - - - -
[2]4tyg.a . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . * . . . . . * * . . . * . * . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4qq5.a:37o
4qqc.a:37o
4qqj.a is apo
4r6v.a:fi3
4tyi.a:38o
4tyj.a:0li
4uxq.a:0li
4xcu.a:40m
5jkg.a:6lf
4tyg.a is apo
[1] 4qq5.a
0.6
1.3 - 0.9 0.5 3.9 4.1 1.7 2.1 -
[1] 4qqc.a 1.1
0.7
- 1.7 0.3 4.3 4.4 1.0 1.9 -
[1] 4qqj.a 1.2 1.0
-
1.6 0 7.8 8.2 1.7 0.2 -
[1] 4r6v.a 1.0 1.8 -
0.7
0.5 3.7 4.0 1.1 2.2 -
[1] 4tyi.a 0.5 0.2 - 1.0
0
7.6 7.4 1.7 0 -
[1] 4tyj.a 1.3 1.0 - 2.1 1.4
0
0 1.6 3.2 -
[1] 4uxq.a 1.4 1.1 - 1.7 1.3 0
0
1.9 3.3 -
[1] 4xcu.a 0.8 0.1 - 1.4 0 8.1 7.6
0.5
0 -
[1] 5jkg.a 5.7 5.3 - 5.7 0 10 11 3.6
0
-
[2] 4tyg.a 6.4 6.5 - 8.6 1.9 8.6 8.4 3.0 3.6
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4qq5.a
4qqc.a
4qqj.a
4r6v.a
4tyi.a
4tyj.a
4uxq.a
4xcu.a
5jkg.a
4tyg.a
[1] 4qq5.a
0
.06 .22 .04 .19 .18 .17 .25 .29 .38
[1] 4qqc.a .06
0
.23 .08 .20 .18 .18 .22 .24 .37
[1] 4qqj.a .22 .23
0
.23 .09 .15 .15 .10 .17 .23
[1] 4r6v.a .04 .08 .23
0
.19 .18 .17 .25 .31 .39
[1] 4tyi.a .19 .20 .09 .19
0
.13 .12 .10 .19 .23
[1] 4tyj.a .18 .18 .15 .18 .13
0
.02 .14 .25 .28
[1] 4uxq.a .17 .18 .15 .17 .12 .02
0
.15 .25 .29
[1] 4xcu.a .25 .22 .10 .25 .10 .14 .15
0
.21 .23
[1] 5jkg.a .29 .24 .17 .31 .19 .25 .25 .21
0
.31
[2] 4tyg.a .38 .37 .23 .39 .23 .28 .29 .23 .31
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 3.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4qq5.a
4qqc.a
4qqj.a
4r6v.a
4tyi.a
4tyj.a
4uxq.a
4xcu.a
5jkg.a
4tyg.a
[1] 4qq5.a
0
0.6 1.7 0.3 2.1 3.5 3.0 1.8 2.4 2.3
[1] 4qqc.a 0.6
0
1.6 0.7 2.1 2.5 2.4 1.7 2.4 2.4
[1] 4qqj.a 1.7 1.6
0
1.7 0.9 4.1 3.3 3.0 1.7 5.8
[1] 4r6v.a 0.3 0.7 1.7
0
2.2 3.5 2.9 1.9 2.5 2.3
[1] 4tyi.a 2.1 2.1 0.9 2.2
0
4.3 3.4 1.6 2.2 1.3
[1] 4tyj.a 3.5 2.5 4.1 3.5 4.3
0
2.2 5.1 3.8 4.5
[1] 4uxq.a 3.0 2.4 3.3 2.9 3.4 2.2
0
4.3 3.5 6.0
[1] 4xcu.a 1.8 1.7 3.0 1.9 1.6 5.1 4.3
0
1.6 5.1
[1] 5jkg.a 2.4 2.4 1.7 2.5 2.2 3.8 3.5 1.6
0
2.8
[2] 4tyg.a 2.3 2.4 5.8 2.3 1.3 4.5 6.0 5.1 2.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 2.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4qq5.a
4qqc.a
4qqj.a
4r6v.a
4tyi.a
4tyj.a
4uxq.a
4xcu.a
5jkg.a
4tyg.a
[1] 4qq5.a
0
0.8 2.5 0.6 3.2 3.5 3.3 2.6 3.1 3.4
[1] 4qqc.a 0.8
0
2.5 0.9 3.3 2.9 3.0 2.6 3.0 3.5
[1] 4qqj.a 2.5 2.5
0
2.5 1.4 4.1 4.2 3.9 2.4 7.3
[1] 4r6v.a 0.6 0.9 2.5
0
3.3 3.5 3.3 2.7 3.2 3.4
[1] 4tyi.a 3.2 3.3 1.4 3.3
0
4.5 3.8 2.1 2.9 1.8
[1] 4tyj.a 3.5 2.9 4.1 3.5 4.5
0
2.3 5.0 4.3 4.6
[1] 4uxq.a 3.3 3.0 4.2 3.3 3.8 2.3
0
5.1 4.0 7.3
[1] 4xcu.a 2.6 2.6 3.9 2.7 2.1 5.0 5.1
0
2.4 6.2
[1] 5jkg.a 3.1 3.0 2.4 3.2 2.9 4.3 4.0 2.4
0
3.6
[2] 4tyg.a 3.4 3.5 7.3 3.4 1.8 4.6 7.3 6.2 3.6
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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