FGFR2_HUMAN_455_769

Fibroblast growth factor receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (FGFR2_HUMAN):D: Protein kinase (487:493,495,515,517,534,538,548,564:567,570,571,630,631,633,643,644,664)487:493,495,515,517,534,538,548,564:567,570,571,630,631,633,643,644,664

Full PDB list

1gjo,1oec,2psq,2pvf,2pvy,2pwl,2py3,2pz5,2pzp,2pzr,2q0b,3b2t,3cly,3ri1,4j95,4j96,4j97,4j98,4j99,5eg3 (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
L
4
8
7
G
4
8
8
E
4
8
9
G
4
9
0
C
4
9
1
F
4
9
2
G
4
9
3
V
4
9
5
A
5
1
5
K
5
1
7
E
5
3
4
M
5
3
8
I
5
4
8
V
5
6
4
E
5
6
5
Y
5
6
6
A
5
6
7
G
5
7
0
N
5
7
1
R
6
3
0
N
6
3
1
L
6
3
3
A
6
4
3
D
6
4
4
R
6
6
4
[1]1oec.a aa2 32 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ri1.a 3rh 21 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3b2t.a m33 27 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2pvf.a acp,mg,mg 33 . . . . A . . . . . . . . . . . . . . . . . . . .
[1]2psq.a none . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2py3.b acp,mg,mg 33 . . - - - - . . . . . . . . G . . . . . . . . . .
[1]2pz5.b acp,mg,mg 33 . - - - - - - . . . . . . . . . . . . . . . . . .
[1]2q0b.a acp 10 . - - - - - . . . . . . . . A . . . . . . . . . .
[1]4j96.a none . . . . A . . . . . . . . . . . . . . . . . . . .
[1]4j97.a acp 23 . . . - - - . . . . . . . . . . . . . . . . . . .
[1]4j98.b acp 31 . . . . A . . . . . . . . . . . . . . . . . . . .
[1]4j99.c acp,mg 32 . . . . A . . . . . . . . . . . . . . . . . . . .
[1]5eg3.a acp,mg,mg 33 . . . . A . . . . . . . . . A . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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