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FES_HUMAN_552_822

Tyrosine-protein kinase Fes/Fps [Protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (FES_HUMAN):D: Protein kinase (567:570, 575, 588, 590, 607, 620, 636:640, 642, 643, 646, 687, 688, 690, 700, 701)567:570, 575, 588, 590, 607, 620, 636:640, 642, 643, 646, 687, 688, 690, 700, 701
Cofactors (cF):aceIYESL

Full PDB list

3bkb, 3cbl, 3cd3, 4e93 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF
I
5
6
7
G
5
6
8
R
5
6
9
G
5
7
0
V
5
7
5
A
5
8
8
K
5
9
0
E
6
0
7
M
6
3
6
E
6
3
7
L
6
3
8
V
6
3
9
Q
6
4
0
G
6
4
2
D
6
4
3
T
6
4
6
R
6
8
7
N
6
8
8
L
6
9
0
S
7
0
0
D
7
0
1
[1]3cbl.a stu35 . . . . . . . . . . . . . . . . . . . . . aceIYESL
[1]4e93.a gui42 . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 cF
I
5
6
7
G
5
6
8
R
5
6
9
G
5
7
0
V
5
7
5
A
5
8
8
K
5
9
0
E
6
0
7
V
6
2
0
M
6
3
6
E
6
3
7
L
6
3
8
V
6
3
9
Q
6
4
0
G
6
4
2
D
6
4
3
T
6
4
6
R
6
8
7
N
6
8
8
L
6
9
0
S
7
0
0
D
7
0
1
[1]3cbl.a . . . . . . . . . . . . . . . . . . . . . . aceIYESL
[1]4e93.a . . . . . . * . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3cbl.a:stu
4e93.a:gui
[1] 3cbl.a
0
0.1
[1] 4e93.a 1.0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3cbl.a
4e93.a
[1] 3cbl.a
0
.05
[1] 4e93.a .05
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3cbl.a
4e93.a
[1] 3cbl.a
0
0.8
[1] 4e93.a 0.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3cbl.a
4e93.a
[1] 3cbl.a
0
1.3
[1] 4e93.a 1.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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