FAK2_HUMAN_415_692

Protein-tyrosine kinase 2-beta [Protein kinase superfamily. Tyr protein kinase family. FAK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (FAK2_HUMAN):D: Protein kinase (431:436,439,455,457,473,474,477,478,481,486,487,502:505,508,509,512,540,547,553,556,565:568,572,576)431:436,439,455,457,473,474,477,478,481,486,487,502:505,508,509,512,540,547,553,556,565:568,572,576

Full PDB list

3cc6,3et7,3fzo,3fzp,3fzr,3fzs,3fzt,3h3c,4h1j,4h1m (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
L
4
3
1
G
4
3
2
E
4
3
3
G
4
3
4
F
4
3
5
F
4
3
6
V
4
3
9
A
4
5
5
K
4
5
7
S
4
7
3
E
4
7
4
I
4
7
7
M
4
7
8
L
4
8
1
I
4
8
6
V
4
8
7
M
5
0
2
E
5
0
3
L
5
0
4
Y
5
0
5
G
5
0
8
E
5
0
9
H
5
1
2
L
5
4
0
H
5
4
7
R
5
5
3
L
5
5
6
L
5
6
5
G
5
6
6
D
5
6
7
F
5
6
8
R
5
7
2
D
5
7
6
[1]4h1j.a 0yh 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3fzt.a 4jz 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]3h3c.a p1e 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - -
[1]4h1m.a 0yj 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - -
[2]3fzr.a 3jz 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -
[2]3et7.a 349 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -
[1]3fzs.a b96 39 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - -
[1]3cc6.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -
[2]3fzp.a ags 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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