If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

FABPH_HUMAN_1_133

Fatty acid-binding protein, heart [Calycin superfamily. Fatty-acid binding protein (FABP) family]

Composition of the binding site

Protein chains monomer
A1 (FABPH_HUMAN):17, 20, 21, 24, 26, 30, 34, 37, 39, 54, 56, 58:61, 76, 77, 79, 105, 107, 116, 118, 127, 12917, 20, 21, 24, 26, 30, 34, 37, 39, 54, 56, 58:61, 76, 77, 79, 105, 107, 116, 118, 127, 129

Full PDB list

1hmr, 1hms, 1hmt, 2hmb, 3rsw, 3wbg, 3wvm, 3wxq, 4tjz, 4tkb, 4tkh, 4tkj, 4wbk, 5b27, 5b28, 5b29, 5ce4, 5hz9 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
F
1
7
Y
2
0
M
2
1
L
2
4
V
2
6
T
3
0
A
3
4
P
3
9
T
5
4
S
5
6
F
5
8
K
5
9
T
6
1
A
7
6
D
7
7
R
7
9
L
1
0
5
L
1
1
6
L
1
1
8
R
1
2
7
Y
1
2
9
[1]1hmr.a ela20 . . . . . . . . . . . . . . . . . . . . .
[1]3rsw.a none . . . . . . . . . . . . . . . . . . . . .
[1]3wbg.b 2an21 . . . . . . . . . . . . . . . . . . . . .
[1]3wvm.a ste20 . . . . . . . . . . . . . . . . . . . . .
[1]4tjz.a dka12 . . . . . . . . . . . . . . . . . . . . .
[1]4tkb.a dao14 . . . . . . . . . . . . . . . . . . . . .
[1]4tkh.a myr16 . . . . . . . . . . . . . . . . . . . . .
[1]4tkj.a plm18 . . . . . . . . . . . . . . . . . . . . .
[1]5b27.a plm18 . . S . . . . . . . . . . . . . . . . . .
[1]5b28.a plm18 V . . . . . . . . . . . . . . . . . . . .
[1]5ce4.a ola20 . . . . . . . . . . . . . . . . . . . . .
[1]5hz9.a 5m821 . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
F
1
7
Y
2
0
M
2
1
L
2
4
V
2
6
T
3
0
A
3
4
T
3
7
P
3
9
T
5
4
S
5
6
F
5
8
K
5
9
N
6
0
T
6
1
A
7
6
D
7
7
R
7
9
L
1
0
5
R
1
0
7
L
1
1
6
L
1
1
8
R
1
2
7
Y
1
2
9
[1]1hmr.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]3rsw.a . . . . . . . . . . . * . . . . . . . . . . . .
[1]3wbg.b . . . . . . . . . . . * . . . . . . . . . . . .
[1]3wvm.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]4tjz.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]4tkb.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]4tkh.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]4tkj.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]5b27.a . . S . . . . . . . . . . . . . . . . . . . . .
[1]5b28.a V . . . . . . . . . . . . . . . . . . . . . . .
[1]5ce4.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]5hz9.a . . . . . . . . . . . * . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1hmr.a:ela
3rsw.a is apo
3wbg.b:2an
3wvm.a:ste
4tjz.a:dka
4tkb.a:dao
4tkh.a:myr
4tkj.a:plm
5b27.a:plm
5b28.a:plm
5ce4.a:ola
5hz9.a:5m8
[1] 1hmr.a
0
- 0 0 0 0 0 0 0 0 0 0.1
[1] 3rsw.a 1.1
-
0.4 1.1 0.2 1.6 0.9 1.2 1.0 1.3 1.4 0.3
[1] 3wbg.b 0.7 -
0
0.7 0.3 1.0 0.4 0.5 0.6 0.5 0.6 0.2
[1] 3wvm.a 0 - 0
0
0 0 0 0 0 0 0 0.1
[1] 4tjz.a 0.1 - 0 0.1
0
0.1 0 0.1 0 0.1 0.1 0.1
[1] 4tkb.a 0.1 - 0 0 0
0
0 0 0 0.1 0 0.1
[1] 4tkh.a 0.1 - 0 0 0 0
0
0 0 0 0 0.1
[1] 4tkj.a 0.1 - 0 0 0 0.1 0
0
0 0 0 0.1
[1] 5b27.a 0.1 - 0 0 0 0.1 0 0
0
0 0 0.1
[1] 5b28.a 0.1 - 0 0 0 0 0 0 0
0
0 0.1
[1] 5ce4.a 0 - 0 0 0 0.1 0 0 0 0
0
0.1
[1] 5hz9.a 1.0 - 0 1.0 0.3 1.9 0.6 0.8 1.0 0.7 1.0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1hmr.a
3rsw.a
3wbg.b
3wvm.a
4tjz.a
4tkb.a
4tkh.a
4tkj.a
5b27.a
5b28.a
5ce4.a
5hz9.a
[1] 1hmr.a
0
.09 .05 0 .01 .01 0 .01 .01 0 0 .09
[1] 3rsw.a .09
0
.05 .09 .08 .08 .08 .08 .08 .08 .08 .04
[1] 3wbg.b .05 .05
0
.05 .05 .05 .05 .05 .05 .05 .05 .06
[1] 3wvm.a 0 .09 .05
0
.01 .01 0 .01 .01 0 0 .09
[1] 4tjz.a .01 .08 .05 .01
0
.01 0 0 0 0 .01 .09
[1] 4tkb.a .01 .08 .05 .01 .01
0
0 .01 .01 0 .01 .09
[1] 4tkh.a 0 .08 .05 0 0 0
0
0 0 0 .01 .08
[1] 4tkj.a .01 .08 .05 .01 0 .01 0
0
0 0 .01 .09
[1] 5b27.a .01 .08 .05 .01 0 .01 0 0
0
0 .01 .09
[1] 5b28.a 0 .08 .05 0 0 0 0 0 0
0
.01 .08
[1] 5ce4.a 0 .08 .05 0 .01 .01 .01 .01 .01 .01
0
.08
[1] 5hz9.a .09 .04 .06 .09 .09 .09 .08 .09 .09 .08 .08
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1hmr.a
3rsw.a
3wbg.b
3wvm.a
4tjz.a
4tkb.a
4tkh.a
4tkj.a
5b27.a
5b28.a
5ce4.a
5hz9.a
[1] 1hmr.a
0
1.0 0.5 0.2 0.3 0.3 0.3 0.3 0.3 0.3 0.1 0.5
[1] 3rsw.a 1.0
0
1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.0
[1] 3wbg.b 0.5 1.1
0
0.5 0.4 0.4 0.4 0.5 0.5 0.5 0.4 0.4
[1] 3wvm.a 0.2 1.1 0.5
0
0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.5
[1] 4tjz.a 0.3 1.1 0.4 0.1
0
0.1 0.1 0.1 0.2 0.2 0.2 0.5
[1] 4tkb.a 0.3 1.1 0.4 0.1 0.1
0
0.1 0.1 0.2 0.1 0.2 0.5
[1] 4tkh.a 0.3 1.1 0.4 0.1 0.1 0.1
0
0.1 0.1 0.1 0.2 0.5
[1] 4tkj.a 0.3 1.1 0.5 0.1 0.1 0.1 0.1
0
0.1 0.1 0.2 0.5
[1] 5b27.a 0.3 1.1 0.5 0.1 0.2 0.2 0.1 0.1
0
0.1 0.2 0.5
[1] 5b28.a 0.3 1.1 0.5 0.1 0.2 0.1 0.1 0.1 0.1
0
0.2 0.5
[1] 5ce4.a 0.1 1.0 0.4 0.2 0.2 0.2 0.2 0.2 0.2 0.2
0
0.5
[1] 5hz9.a 0.5 1.0 0.4 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1hmr.a
3rsw.a
3wbg.b
3wvm.a
4tjz.a
4tkb.a
4tkh.a
4tkj.a
5b27.a
5b28.a
5ce4.a
5hz9.a
[1] 1hmr.a
0
1.9 0.7 0.4 0.4 0.4 0.5 0.5 0.5 0.5 0.2 0.7
[1] 3rsw.a 1.9
0
1.9 2.0 2.0 2.0 2.0 2.1 2.1 1.7 1.9 1.8
[1] 3wbg.b 0.7 1.9
0
0.8 0.8 0.8 0.8 0.8 0.8 0.9 0.6 0.6
[1] 3wvm.a 0.4 2.0 0.8
0
0.4 0.1 0.1 0.1 0.1 0.3 0.4 0.9
[1] 4tjz.a 0.4 2.0 0.8 0.4
0
0.4 0.4 0.4 0.4 0.5 0.4 0.8
[1] 4tkb.a 0.4 2.0 0.8 0.1 0.4
0
0.1 0.2 0.2 0.3 0.4 0.9
[1] 4tkh.a 0.5 2.0 0.8 0.1 0.4 0.1
0
0.1 0.1 0.3 0.4 0.9
[1] 4tkj.a 0.5 2.1 0.8 0.1 0.4 0.2 0.1
0
0.1 0.3 0.4 0.9
[1] 5b27.a 0.5 2.1 0.8 0.1 0.4 0.2 0.1 0.1
0
0.3 0.4 0.9
[1] 5b28.a 0.5 1.7 0.9 0.3 0.5 0.3 0.3 0.3 0.3
0
0.5 0.9
[1] 5ce4.a 0.2 1.9 0.6 0.4 0.4 0.4 0.4 0.4 0.4 0.5
0
0.7
[1] 5hz9.a 0.7 1.8 0.6 0.9 0.8 0.9 0.9 0.9 0.9 0.9 0.7
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...