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FAAA_MOUSE_1_419

Fumarylacetoacetase [FAH family]

Composition of the binding site

Protein chains homodimer
A1 (FAAA_MOUSE):126:128, 133, 137, 141, 142, 159, 199, 201, 233, 237, 240, 244, 253, 349, 350126:128, 133, 137, 141, 142, 159, 199, 201, 233, 237, 240, 244, 253, 349, 350
A2 (FAAA_MOUSE):246, 247246, 247
Metals (Me):Ca/Mn

Full PDB list

1hyo, 1qcn, 1qco, 1qqj, 2hzy (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 A2 Me
D
1
2
6
F
1
2
7
Y
1
2
8
H
1
3
3
V
1
3
7
F
1
4
1
R
1
4
2
Y
1
5
9
E
1
9
9
E
2
0
1
D
2
3
3
R
2
3
7
Q
2
4
0
Y
2
4
4
K
2
5
3
G
3
4
9
T
3
5
0
P
2
4
6
L
2
4
7
[1]1hyo.a hbu11 . . . . . . . . . . . . . . . . . . . Ca
[1]1qcn.a none . . . . . . . . . . . . . . . . . . . Ca
[1]1qco.a aae,fum15 . . . . . . . . . . . . . . . . . . . Ca
[1]2hzy.a dhj15 . . . . . . . . . . . . . . . . . . . Mn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 A2 Me
D
1
2
6
F
1
2
7
Y
1
2
8
H
1
3
3
V
1
3
7
F
1
4
1
R
1
4
2
Y
1
5
9
E
1
9
9
E
2
0
1
D
2
3
3
R
2
3
7
Q
2
4
0
Y
2
4
4
K
2
5
3
G
3
4
9
T
3
5
0
P
2
4
6
L
2
4
7
[1]1hyo.a . . . . . . . . . . . . . . . . . . . Ca
[1]1qcn.a . . . . . . . . . . . . . . . . . . . Ca
[1]1qco.a . . . . . . . . . . . . . . . . . . . Ca
[1]2hzy.a . . . . . . * . . . . . . . . . . . . Mn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1hyo.a:hbu
1qcn.a is apo
1qco.a:aae,fum
2hzy.a:dhj
[1] 1hyo.a
0
- 0.1 0.2
[1] 1qcn.a 0.1
-
0.3 0.4
[1] 1qco.a 0 -
0
0.1
[1] 2hzy.a 0.1 - 1.2
0.2
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1hyo.a
1qcn.a
1qco.a
2hzy.a
[1] 1hyo.a
0
.03 .01 .07
[1] 1qcn.a .03
0
.02 .08
[1] 1qco.a .01 .02
0
.07
[1] 2hzy.a .07 .08 .07
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1hyo.a
1qcn.a
1qco.a
2hzy.a
[1] 1hyo.a
0
0.2 0.2 0.2
[1] 1qcn.a 0.2
0
0.3 0.4
[1] 1qco.a 0.2 0.3
0
0.2
[1] 2hzy.a 0.2 0.4 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1hyo.a
1qcn.a
1qco.a
2hzy.a
[1] 1hyo.a
0
0.6 0.6 0.8
[1] 1qcn.a 0.6
0
0.6 0.9
[1] 1qco.a 0.6 0.6
0
0.6
[1] 2hzy.a 0.8 0.9 0.6
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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