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FA8_HUMAN_2190_2349

Coagulation factor VIII [Multicopper oxidase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (FA8_HUMAN):D: F5/8 type C 2 (2277, 2330:2334)2277, 2330:2334

Full PDB list

1d7p, 1iqd, 3hnb, 3hny, 3hob, 4ki5, 4pt6, 4xzu (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1
K
2
2
7
7
Q
2
3
3
0
S
2
3
3
1
W
2
3
3
2
H
2
3
3
4
[1]3hnb.m 76831 . . . . .
[1]3hny.m none . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
K
2
2
7
7
Q
2
3
3
0
S
2
3
3
1
W
2
3
3
2
V
2
3
3
3
H
2
3
3
4
[1]3hnb.m . . . . . .
[1]3hny.m . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3hnb.m:768
3hny.m is apo
[1] 3hnb.m
0.4
-
[1] 3hny.m 0.6
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3hnb.m
3hny.m
[1] 3hnb.m
0
.03
[1] 3hny.m .03
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3hnb.m
3hny.m
[1] 3hnb.m
0
0.1
[1] 3hny.m 0.1
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3hnb.m
3hny.m
[1] 3hnb.m
0
0.5
[1] 3hny.m 0.5
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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