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F261_HUMAN_251_441

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (F261_HUMAN):R: Fructose-2,6-bisphosphatase (258, 259, 265, 270, 271, 308, 328, 329, 339, 342, 350, 353, 357, 362, 368, 393:395, 398, 413, 448, 467)258, 259, 265, 270, 271, 308, 328, 329, 339, 342, 350, 353, 357, 362, 368, 393:395, 398, 413, 448, 467

Full PDB list

1c7z, 1c80, 1c81, 1fbt, 1k6m, 1tip (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
R
2
5
8
H
2
5
9
N
2
6
5
I
2
7
0
G
2
7
1
R
3
0
8
E
3
2
8
I
3
2
9
Y
3
3
9
F
3
5
0
R
3
5
3
K
3
5
7
Y
3
6
2
Y
3
6
8
H
3
9
3
Q
3
9
4
A
3
9
5
R
3
9
8
[1]1c7z.a g3h10 . . . . . . . . . . . . . . . . . .
[1]1k6m.a none . . . . . . . . . . . . . . . . . .
[1]1tip.a f6p16 . * . . . . . . . . . . . . . . . .
[2]1c80.b gtp32 . . . . . . . . . . . . . . . . . .
[2]1c81.a fdq18 . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
R
2
5
8
H
2
5
9
N
2
6
5
I
2
7
0
G
2
7
1
R
3
0
8
E
3
2
8
I
3
2
9
Y
3
3
9
I
3
4
2
F
3
5
0
R
3
5
3
K
3
5
7
Y
3
6
2
Y
3
6
8
H
3
9
3
Q
3
9
4
A
3
9
5
R
3
9
8
P
4
1
3
R
4
4
8
V
4
6
7
[1]1c7z.a . . . . . . . . * . . * . . . . . . . . - -
[1]1k6m.a . . . . . . . . * . . . . . . . * . . . . .
[1]1tip.a . nep . . . . . . * . . * . . . . . . . . - -
[2]1c80.b . . . . . . . . . . . . . . . . . . . . - -
[2]1c81.a . . . . . . . . . . . . . . . . . . . . - -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1c7z.a:g3h
1k6m.a is apo
1tip.a:f6p
1c80.b:gtp
1c81.a:fdq
[1] 1c7z.a
0.1
- 0.1 6.1 0.6
[1] 1k6m.a 0.5
-
0.2 7.9 0.9
[1] 1tip.a 0.3 -
0
6.3 3.0
[2] 1c80.b 0 - 0
0.3
0.4
[2] 1c81.a 0 - 0 1.5
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1c7z.a
1k6m.a
1tip.a
1c80.b
1c81.a
[1] 1c7z.a
0
.15 .15 .27 .27
[1] 1k6m.a .15
0
.28 .36 .36
[1] 1tip.a .15 .28
0
.42 .39
[2] 1c80.b .27 .36 .42
0
.07
[2] 1c81.a .27 .36 .39 .07
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1c7z.a
1k6m.a
1tip.a
1c80.b
1c81.a
[1] 1c7z.a
0
0.4 0.2 0.3 0.4
[1] 1k6m.a 0.4
0
0.4 0.5 0.5
[1] 1tip.a 0.2 0.4
0
0.3 0.3
[2] 1c80.b 0.3 0.5 0.3
0
0.3
[2] 1c81.a 0.4 0.5 0.3 0.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1c7z.a
1k6m.a
1tip.a
1c80.b
1c81.a
[1] 1c7z.a
0
0.9 0.4 1.3 1.6
[1] 1k6m.a 0.9
0
0.9 1.5 1.9
[1] 1tip.a 0.4 0.9
0
1.4 1.6
[2] 1c80.b 1.3 1.5 1.4
0
1.0
[2] 1c81.a 1.6 1.9 1.6 1.0
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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