EZH2_HUMAN_519_746

Histone-lysine N-methyltransferase EZH2 [Class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EZH2_HUMAN):R: Interaction with DNMT1, DNMT3A and DNMT3B (109:111)
D: SET (621:624,657,658,661:665,678,685:689,726)
733:736
109:111,621:624,657,658,661:665,678,685:689,726,733:736

Full PDB list

4mi0,4mi5,5hyn,5ij7,5ij8 (redundant pocketome entry)

Contact map

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ligand
A1
I
1
0
9
M
1
1
0
Y
1
1
1
V
6
2
1
A
6
2
2
G
6
2
3
W
6
2
4
V
6
5
7
Y
6
5
8
Y
6
6
1
M
6
6
2
C
6
6
3
S
6
6
4
F
6
6
5
T
6
7
8
R
6
8
5
F
6
8
6
A
6
8
7
N
6
8
8
H
6
8
9
Y
7
2
6
A
7
3
3
L
7
3
4
K
7
3
5
Y
7
3
6
[2]4mi0.a none - - - . . . . . - . . . . . . . . . . . . - - - -
[1]5ij8.b 6bn 36 . . . . . . . . . . . . . . . . . . . . . . - - -
[1]5hyn.f sah 26 . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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