If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

ERR1_HUMAN_192_423

Steroid hormone receptor ERR1 [Nuclear hormone receptor family. NR3 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (ERR1_HUMAN):D: NR LBD (224:229, 231, 232, 235, 266, 269, 270, 273, 276, 286, 290, 292, 300:302, 309, 395, 399, 402, 404, 408:410, 414)224:229, 231, 232, 235, 266, 269, 270, 273, 276, 286, 290, 292, 300:302, 309, 395, 399, 402, 404, 408:410, 414

Full PDB list

1xb7, 2pjl, 3d24, 3k6p (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
V
2
2
5
L
2
2
8
C
2
2
9
L
2
3
1
F
2
3
2
E
2
3
5
M
2
6
6
L
2
6
9
V
2
7
0
V
2
7
3
R
2
7
6
F
2
8
6
L
2
9
0
A
3
0
0
G
3
0
1
L
3
0
2
L
3
0
9
V
3
9
5
F
3
9
9
V
4
0
2
L
4
0
4
V
4
0
8
M
4
1
0
[1]2pjl.a 04725 . . S . . . . . . . . . . . . . . . . . . . .
[1]3k6p.a 5fb29 . . . . . . . . . . . . . . . . . . . . . . .
[2]1xb7.a none . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
A
2
2
4
V
2
2
5
A
2
2
6
T
2
2
7
L
2
2
8
C
2
2
9
L
2
3
1
F
2
3
2
E
2
3
5
M
2
6
6
L
2
6
9
V
2
7
0
V
2
7
3
R
2
7
6
F
2
8
6
L
2
9
0
L
2
9
2
A
3
0
0
G
3
0
1
L
3
0
2
L
3
0
9
V
3
9
5
F
3
9
9
V
4
0
2
L
4
0
4
V
4
0
8
P
4
0
9
M
4
1
0
F
4
1
4
[1]2pjl.a . . . . . S . . . . . . . . . . . . . . . . . . * . . . .
[1]3k6p.a . . . . * . . . . . . . . . . . . . . . . . . . . . . . .
[2]1xb7.a . * . . * * . * . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2pjl.a:047
3k6p.a:5fb
1xb7.a is apo
[1] 2pjl.a
0
3.7 -
[1] 3k6p.a 3.3
0.3
-
[2] 1xb7.a 9.9 7.3
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2pjl.a
3k6p.a
1xb7.a
[1] 2pjl.a
0
.22 .53
[1] 3k6p.a .22
0
.36
[2] 1xb7.a .53 .36
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 4.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2pjl.a
3k6p.a
1xb7.a
[1] 2pjl.a
0
4.6 4.6
[1] 3k6p.a 4.6
0
4.5
[2] 1xb7.a 4.6 4.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 4.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2pjl.a
3k6p.a
1xb7.a
[1] 2pjl.a
0
5.5 5.5
[1] 3k6p.a 5.5
0
4.5
[2] 1xb7.a 5.5 4.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...