ERN1_HUMAN_554_974

Serine/threonine-protein kinase/endoribonuclease IRE1 [Protein kinase superfamily. Ser/Thr protein kinase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ERN1_HUMAN):D: Protein kinase (577:581,584,586,597,599,605,608,609,612,613,616,626,628,640,642:648,651,679,684:686,690,692,693,695,709:712)577:581,584,586,597,599,605,608,609,612,613,616,626,628,640,642:648,651,679,684:686,690,692,693,695,709:712

Full PDB list

3p23,4pl3,4pl4,4pl5,4u6r,4yz9,4yzc,4yzd,4z7g,4z7h,5hgi (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
L
5
7
7
G
5
7
8
H
5
7
9
G
5
8
0
A
5
8
1
T
5
8
4
V
5
8
6
A
5
9
7
K
5
9
9
C
6
0
5
F
6
0
8
A
6
0
9
E
6
1
2
V
6
1
3
L
6
1
6
I
6
2
6
Y
6
2
8
I
6
4
0
I
6
4
2
E
6
4
3
L
6
4
4
C
6
4
5
A
6
4
6
A
6
4
7
T
6
4
8
E
6
5
1
L
6
7
9
I
6
8
4
V
6
8
5
H
6
8
6
K
6
9
0
H
6
9
2
N
6
9
3
L
6
9
5
I
7
0
9
S
7
1
0
D
7
1
1
F
7
1
2
[3]4yz9.a 4k7 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4z7h.b 4l5 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4u6r.a 3e4 43 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]3p23.b adp,mg 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yzc.a stu 35 . . . . . . . . . - - - . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4yzd.c adp 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5hgi.a none . . . - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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