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ERBB3_HUMAN_683_1020_ATPsite

Receptor tyrosine-protein kinase erbB-3 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (ERBB3_HUMAN):D: Protein kinase (715:719, 721, 723, 740:742, 772, 785, 787:791, 793, 834, 838, 839, 841, 851, 852, 855, 868)715:719, 721, 723, 740:742, 772, 785, 787:791, 793, 834, 838, 839, 841, 851, 852, 855, 868
Metals (Me):Mg

Full PDB list

3kex, 3lmg, 4otw, 4riw, 4rix, 4riy (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
L
7
1
5
G
7
1
6
S
7
1
7
G
7
1
8
V
7
1
9
V
7
2
3
C
7
4
0
I
7
4
1
K
7
4
2
V
7
7
2
L
7
8
5
T
7
8
7
Q
7
8
8
Y
7
8
9
L
7
9
0
P
7
9
1
G
7
9
3
N
8
3
4
R
8
3
8
N
8
3
9
L
8
4
1
A
8
5
1
D
8
5
2
V
8
5
5
[1]4otw.a db836 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4riw.c anp31 . . . . . . . . . . . . . . . . . . . . . . . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 Me
L
7
1
5
G
7
1
6
S
7
1
7
G
7
1
8
V
7
1
9
G
7
2
1
V
7
2
3
C
7
4
0
I
7
4
1
K
7
4
2
V
7
7
2
L
7
8
5
T
7
8
7
Q
7
8
8
Y
7
8
9
L
7
9
0
P
7
9
1
G
7
9
3
N
8
3
4
R
8
3
8
N
8
3
9
L
8
4
1
A
8
5
1
D
8
5
2
V
8
5
5
Y
8
6
8
[1]4otw.a . . . . . . . . . . . . . . . . . . . . . . . . . -
[1]4riw.c . . . . . . . . . . . . . . . . . . . . . . . * . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4otw.a:db8
4riw.c:anp
[1] 4otw.a
0
0.3
[1] 4riw.c 1.0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4otw.a
4riw.c
[1] 4otw.a
0
.05
[1] 4riw.c .05
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4otw.a
4riw.c
[1] 4otw.a
0
1.7
[1] 4riw.c 1.7
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4otw.a
4riw.c
[1] 4otw.a
0
2.8
[1] 4riw.c 2.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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