EPHB4_HUMAN_598_896

Ephrin type-B receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EPHB4_HUMAN):D: Protein kinase (620:623,629,645:647,664,668,677,691,693:700,744,745,747,757,758)620:623,629,645:647,664,668,677,691,693:700,744,745,747,757,758
Metals (Me):Mg

Full PDB list

2vwu,2vwv,2vww,2vwx,2vwy,2vwz,2vx0,2vx1,2x9f,2xvd,2yn8,3zew,4aw5,4bb4 (redundant pocketome entry)

Contact map

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ligand
A1 Me
V
6
2
0
I
6
2
1
G
6
2
2
A
6
2
3
V
6
2
9
A
6
4
5
I
6
4
6
K
6
4
7
E
6
6
4
M
6
6
8
I
6
7
7
I
6
9
1
T
6
9
3
E
6
9
4
F
6
9
5
M
6
9
6
E
6
9
7
N
6
9
8
G
6
9
9
A
7
0
0
R
7
4
4
N
7
4
5
L
7
4
7
S
7
5
7
D
7
5
8
[1]4bb4.a 32w 30 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2vwu.a 7x1 33 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2vww.a 7x2 30 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2vwv.a 7x3 29 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2vwx.a 7x4 28 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2vwy.a 7x5 28 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2vwz.a 7x6 29 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2vx0.a 7x7 30 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2vx1.a 7x8 27 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2x9f.a x9f 27 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]2xvd.a as6 36 . . . . . . . . . . . . . . . . . . . . . . . . . Mg
[1]4aw5.a 30k 37 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3zew.a stu 35 . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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