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EPHA7_HUMAN_589_908

Ephrin type-A receptor 7 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (EPHA7_HUMAN):D: Protein kinase (639, 647, 663, 665, 682, 686, 689, 695, 711, 712, 714, 765, 774:778)639, 647, 663, 665, 682, 686, 689, 695, 711, 712, 714, 765, 774:778

Full PDB list

2rei, 3dko

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
6
3
9
V
6
4
7
A
6
6
3
K
6
6
5
E
6
8
2
M
6
8
6
F
6
8
9
V
6
9
5
I
7
1
1
E
7
1
2
M
7
1
4
L
7
6
5
S
7
7
5
D
7
7
6
F
7
7
7
[1]3dko.a ihz30 . . . . . . . . . . . . . . .
[2]2rei.a none . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
6
3
9
V
6
4
7
A
6
6
3
K
6
6
5
E
6
8
2
M
6
8
6
F
6
8
9
V
6
9
5
I
7
1
1
E
7
1
2
M
7
1
4
L
7
6
5
V
7
7
4
S
7
7
5
D
7
7
6
F
7
7
7
G
7
7
8
[1]3dko.a . . . . . . . . . . . . . . . . .
[2]2rei.a . . . . * . . . . . . . . * . * .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3dko.a:ihz
2rei.a is apo
[1] 3dko.a
0
-
[2] 2rei.a 9.2
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3dko.a
2rei.a
[1] 3dko.a
0
.54
[2] 2rei.a .54
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3dko.a
2rei.a
[1] 3dko.a
0
2.5
[2] 2rei.a 2.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3dko.a
2rei.a
[1] 3dko.a
0
3.1
[2] 2rei.a 3.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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