EPHA2_HUMAN_594_903_ATPsite

Ephrin type-A receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EPHA2_HUMAN):R: Mediates interaction with ARHGEF16 and ELMO2 (619:623,627,644:646,663,667,670,675,676,690,692:698,702,706,730,735,743,744,746,756:758)
D: Protein kinase (619:623,627,644:646,663,667,670,675,676,690,692:698,702,706,730,735,743,744,746,756:758)
619:623,627,644:646,663,667,670,675,676,690,692:698,702,706,730,735,743,744,746,756:758

Full PDB list

1mqb,4p2k,4pdo,4trl,5ek7,5i9u,5i9v,5i9w,5i9x,5i9y,5i9z,5ia0,5ia1,5ia2,5ia3,5ia4,5ia5 (redundant pocketome entry)

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
6
1
9
G
6
2
0
A
6
2
1
G
6
2
2
E
6
2
3
V
6
2
7
A
6
4
4
I
6
4
5
K
6
4
6
E
6
6
3
M
6
6
7
F
6
7
0
I
6
7
5
I
6
7
6
I
6
9
0
T
6
9
2
E
6
9
3
Y
6
9
4
M
6
9
5
E
6
9
6
N
6
9
7
G
6
9
8
K
7
0
2
E
7
0
6
L
7
3
0
Y
7
3
5
R
7
4
3
N
7
4
4
L
7
4
6
S
7
5
6
D
7
5
7
F
7
5
8
[1]1mqb.b anp 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ia2.a l66 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ia3.a p17 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ia0.a a5b 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ia1.a zzl 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5i9z.a 627 35 . . . . - . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5i9y.a 1n1 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5i9x.a db8 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ia5.a gv0 46 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ia4.a 88z 46 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ek7.b none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5i9v.a ags 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
Similar entries
Feedback