EPAS1_HUMAN_238_353

Endothelial PAS domain-containing protein 1

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EPAS1_HUMAN):D: PAS 2 (244,246,248,252,254,277,280,281,289,292,293,296)
D: PAC (304,307,309,319,321,337,339,341)
302
244,246,248,252,254,277,280,281,289,292,293,296,302,304,307,309,319,321,337,339,341

Full PDB list

3f1n,3f1o,3f1p,3h7w,3h82,4ghi,4gs9,4pky,4zp4,4zph,4zqd,5t0t,5tbm (redundant pocketome entry); 4xt2 (unprocessed)

Contact map

[download in TSV format]
   
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ligand
A1
F
2
4
4
S
2
4
6
H
2
4
8
M
2
5
2
F
2
5
4
A
2
7
7
F
2
8
0
Y
2
8
1
M
2
8
9
S
2
9
2
H
2
9
3
L
2
9
6
V
3
0
2
S
3
0
4
Y
3
0
7
M
3
0
9
L
3
1
9
T
3
2
1
I
3
3
7
C
3
3
9
N
3
4
1
[1]5t0t.a 72q 26 . . . . . . . . . . . . . . . . . . . . .
[1]5tbm.a 79a 26 . . . . . . . . . . . . . . . . . . . . .
[1]3h7w.a 018 20 . . . . . . . . . . . . . . . . . . . . .
[1]3h82.a 020 20 . . . . . . . . . . . . . . . . . . . . .
[1]4gs9.a 0xb 20 . . . . . . . . . . . . . . . . . . . . .
[1]3f1o.a 2xy 20 . . . . . . . . . . . . . . . . . . . . .
[1]4ghi.a 0x3 21 . . . . . . . . . . . . . . . . . . . . .
[1]3f1n.a none . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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