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ENPP6_MOUSE_1_422

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 [Nucleotide pyrophosphatase/phosphodiesterase family]

Composition of the binding site

Protein chains monomer
A1 (ENPP6_MOUSE):32, 71, 72, 75, 92, 105, 140, 157, 188, 190, 193, 197, 241, 35432, 71, 72, 75, 92, 105, 140, 157, 188, 190, 193, 197, 241, 354
Metals (Me):Zn

Full PDB list

5ege, 5egh

Pocket contact map

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PDB.ch
   
ligand
A1 Me
D
3
2
S
7
1
Y
7
2
Y
7
5
N
9
2
Y
1
5
7
Y
1
8
8
E
1
9
0
D
1
9
3
H
1
9
7
H
2
4
1
H
3
5
4
[1]5ege.a none . . . . . . . . . . . . Zn
[1]5egh.b pc11 . . . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 Me
D
3
2
S
7
1
Y
7
2
Y
7
5
N
9
2
I
1
0
5
P
1
4
0
Y
1
5
7
Y
1
8
8
E
1
9
0
D
1
9
3
H
1
9
7
H
2
4
1
H
3
5
4
[1]5ege.a . . . . . . . . . . . . . . Zn
[1]5egh.b . . . . . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
5ege.a is apo
5egh.b:pc
[1] 5ege.a
-
0.3
[1] 5egh.b -
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
5ege.a
5egh.b
[1] 5ege.a
0
.01
[1] 5egh.b .01
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5ege.a
5egh.b
[1] 5ege.a
0
0.1
[1] 5egh.b 0.1
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5ege.a
5egh.b
[1] 5ege.a
0
0.2
[1] 5egh.b 0.2
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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