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ENO_SYNP6_4_429

Enolase [Enolase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (ENO_SYNP6):R: Substrate binding (367:369)
45, 46, 168, 287, 314, 339, 390
45, 46, 168, 287, 314, 339, 367:369, 390
Metals (Me):Ca/Mg

Full PDB list

4rop, 5j04

Pocket contact map

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PDB.ch
   
ligand
A1 Me
G
4
5
D
3
1
4
K
3
3
9
H
3
6
7
R
3
6
8
S
3
6
9
K
3
9
0
[1]4rop.a none . . . . . . . Ca,Mg
[1]5j04.a pep10 . . . . . . . Ca,Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 Me
G
4
5
A
4
6
E
1
6
8
E
2
8
7
D
3
1
4
K
3
3
9
H
3
6
7
R
3
6
8
S
3
6
9
K
3
9
0
[1]4rop.a . . . . . . . . . . Ca,Mg
[1]5j04.a . . . . . . . . . . Ca,Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4rop.a is apo
5j04.a:pep
[1] 4rop.a
-
0.1
[1] 5j04.a -
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4rop.a
5j04.a
[1] 4rop.a
0
0
[1] 5j04.a 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4rop.a
5j04.a
[1] 4rop.a
0
2.3
[1] 5j04.a 2.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4rop.a
5j04.a
[1] 4rop.a
0
1.9
[1] 5j04.a 1.9
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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