EHMT2_HUMAN_914_1192

Histone-lysine N-methyltransferase EHMT2 [Class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EHMT2_HUMAN):D: SET (1067,1074,1077,1078,1080,1083:1088,1091,1096,1098,1121,1123,1136,1152,1154)
R: Interaction with histone H3 (1074,1077,1078,1080,1083:1088,1091)
R: Interaction with histone H3 (1154,1157)
1158,1161,1162
1067,1074,1077,1078,1080,1083:1088,1091,1096,1098,1121,1123,1136,1152,1154,1157,1158,1161,1162
Cofactors (cF):sam
Metals (Me):Zn

Full PDB list

2o8j,3k5k,3rjw,4nvq,5jhn,5jin,5jiy,5jj0,5t0k,5t0m

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF Me
Y
1
0
6
7
D
1
0
7
4
A
1
0
7
7
D
1
0
7
8
R
1
0
8
0
D
1
0
8
3
S
1
0
8
4
Y
1
0
8
5
L
1
0
8
6
F
1
0
8
7
D
1
0
8
8
N
1
0
9
1
V
1
0
9
6
C
1
0
9
8
P
1
1
2
1
R
1
1
2
3
I
1
1
3
6
F
1
1
5
2
Y
1
1
5
4
R
1
1
5
7
F
1
1
5
8
I
1
1
6
1
K
1
1
6
2
[1]3k5k.a dxq 35 . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4nvq.b 2od 24 . . . . . . . . . . . - . . . . . . . . . . . Zn
[1]3rjw.a ciq 37 . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]5jhn.a KQTARAST 59 . . . . . . . . . . . . . . . . . . . . . . . sam Zn
[1]5jhn.b TKQTARAST 66 . . . . . . . . . . . - . . . . . . . . . . . sam Zn
[1]2o8j.a none . . . . . . . . . . . - . . . . . . . . . - - Zn
[1]5jin.a KQTARMST 62 . . . . . . . . . . . . . . . . . . . . . . . sam Zn
[1]5jiy.a KQTARnleST 62 . . . . . . . . . . . . . . . . . . . . . . . sam Zn
[1]5jiy.b TKQTARnleST 69 . . . . . . . . . . . - . . . . . . . . . . . sam
[1]5jj0.b TKQTARMST 69 . . . . . . . . . . . - . . . . . . . . . . . sam
[1]5t0k.a TKQTARMSTG 70 . . . . . . . . . . . - . . . . . . . . . . . sam Zn
[1]5t0m.b TKQTARnleSTG 70 . . . . . . . . . . . . . . . . . . . . . . . sam

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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