EHMT1_HUMAN_986_1266

Histone-lysine N-methyltransferase EHMT1 [Class V-like SAM-binding methyltransferase superfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EHMT1_HUMAN):D: SET (1155,1162,1165:1169,1171:1176,1178,1179,1181,1184,1186,1197,1199,1201,1209,1211,1224,1240:1243)
R: Interaction with histone H3 (1162,1165:1169,1171:1176,1178,1179,1181)
R: S-adenosyl-L-methionine binding (1201)
R: Interaction with histone H3 (1242,1243,1245)
1246,1249,1250
1155,1162,1165:1169,1171:1176,1178,1179,1181,1184,1186,1197,1199,1201,1209,1211,1224,1240:1243,1245,1246,1249,1250
Metals (Me):Zn

Full PDB list

2igq,2rfi,3fpd,3hna,3mo0,3mo2,3mo5,3sw9,3swc,4i51

Contact map

[download in TSV format]
   
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ligand
A1 Me
Y
1
1
5
5
D
1
1
6
2
A
1
1
6
5
D
1
1
6
6
V
1
1
6
7
R
1
1
6
8
E
1
1
6
9
D
1
1
7
1
S
1
1
7
2
Y
1
1
7
3
L
1
1
7
4
F
1
1
7
5
D
1
1
7
6
D
1
1
7
8
N
1
1
7
9
D
1
1
8
1
V
1
1
8
4
C
1
1
8
6
R
1
1
9
7
I
1
1
9
9
H
1
2
0
1
P
1
2
0
9
R
1
2
1
1
I
1
2
2
4
F
1
2
4
0
D
1
2
4
1
Y
1
2
4
2
G
1
2
4
3
R
1
2
4
5
F
1
2
4
6
I
1
2
4
9
K
1
2
5
0
[1]3fpd.b q4a 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3mo0.a e11,e11 70 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3mo0.b e11 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3mo2.a e67 40 . . . . . . . . . . . . . . - - . . . . . . . . . . . . . . . . Zn
[1]3mo5.b e72 39 . . . . . . . . . . . . . . . - . . . . . . . . . . . . . . . . Zn
[1]3sw9.a TARKV 39 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3sw9.b TARKVG 43 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2igq.a none . . . . . . . . . . . . . - - - . . . . . . . . . . . . . . . . Zn
[1]2rfi.a KQTARmlyST 65 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]2rfi.b TARmlyST 47 . . . . . . . . . . . . . - - - . . . . . . . . . . . . . . . .
[1]3hna.a KQTARmlzST 64 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3hna.b ARTKQTARmlzST 87 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3swc.a TARmlyVGRPG 61 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3swc.b ARmlyVGRPG 60 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4i51.a TKQTARldhST 68 . . . . . . . . . . . . . . . . . . . . . . . . . . A . . . . . Zn
[1]4i51.b QTARldhST 49 . . . . . . . . . . . . . . - - . . . . . . . . . . A . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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