EGTD_MYCS2_1_321

Histidine N-alpha-methyltransferase [Methyltransferase superfamily. EgtD family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EGTD_MYCS2):R: S-adenosyl-L-methionine binding (141,142)
R: L-histidine binding (282,284)
36,39,47,56,86:88,92,112:114,140,161:163,166,206,213,216,252
36,39,47,56,86:88,92,112:114,140:142,161:163,166,206,213,216,252,282,284

Full PDB list

4pim,4pin,4pio,4pip,4uy5,4uy6,4uy7 (redundant pocketome entry)

Contact map

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ligand
A1
K
3
6
Y
3
9
F
4
7
Y
5
6
G
8
6
S
8
7
G
8
8
K
9
2
F
1
1
2
D
1
1
3
V
1
1
4
G
1
4
0
D
1
4
1
F
1
4
2
G
1
6
1
S
1
6
2
T
1
6
3
N
1
6
6
Y
2
0
6
T
2
1
3
F
2
1
6
M
2
5
2
E
2
8
2
S
2
8
4
[1]4pin.a avi 13 . . . . . . - . . . . . . . . . . . . . . . . .
[1]4pio.a avi,sah 39 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4pip.c Wsah 41 . . . . . . . . . . . . . . . . . . . . . V A .
[1]4uy5.a none . . . . . . . . . . . . . . . . . . . . . * . .
[1]4uy6.a Hsah 37 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4uy7.a H 11 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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