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EGLN1_HUMAN_181_396

Egl nine homolog 1

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (EGLN1_HUMAN):D: Fe2OG dioxygenase (292:297, 299, 301, 303, 310, 313, 315, 320, 322, 327, 329, 331, 343, 358, 374, 376, 383:385, 389:391)
238:240, 252, 254, 256, 258, 260, 262, 277, 280, 281, 396, 400, 403:415
238:242, 252, 254, 256, 258, 260, 262, 277, 280, 281, 292:297, 299, 301, 303, 310, 313, 315, 320, 322, 327, 329, 331, 343, 358, 374, 376, 383:385, 389:391, 396, 400, 403:415
Metals (Me):Fe/Mn/Ni/Zn

Full PDB list

2g19, 2g1m, 2hbt, 2hbu, 2y33, 2y34, 3hqr, 3hqu, 3ouh, 3oui, 3ouj, 4bqw, 4bqx, 4bqy, 4jzr, 4kbz, 4uwd, 5a3u, 5l9b, 5l9r, 5l9v, 5la9, 5las, 5lat, 5lb6, 5lbb, 5lbc, 5lbe, 5lbf, 5ox5, 5ox6, 5v18 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
Q
2
3
9
L
2
4
0
V
2
4
1
S
2
4
2
R
2
5
2
D
2
5
4
I
2
5
6
W
2
5
8
D
2
7
7
I
2
8
0
R
2
8
1
I
2
9
2
N
2
9
3
G
2
9
4
R
2
9
5
T
2
9
6
K
2
9
7
M
2
9
9
A
3
0
1
Y
3
0
3
Y
3
1
0
H
3
1
3
D
3
1
5
D
3
2
0
R
3
2
2
I
3
2
7
Y
3
2
9
N
3
3
1
L
3
4
3
P
3
5
8
H
3
7
4
V
3
7
6
R
3
8
3
A
3
8
5
W
3
8
9
Y
3
9
0
F
3
9
1
R
3
9
6
K
4
0
0
Y
4
0
3
K
4
0
8
[1]2g1m.a 4hg19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Fe
[1]2y33.a un919 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Zn
[1]2y34.a un9,un938 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - Fe
[1]3hqr.a oga,PYIPMDDDFQL105 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mn
[1]3hqu.a MDDDFQL,un980 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - Fe
[1]3ouh.a 01419 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Fe
[1]3oui.a 42z18 . - - - . . . . . . . . . . . . . . . . . . . - . . . . . . . . . . . . . - - - - Fe
[1]4bqw.a qnm20 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]4jzr.a 4jr30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - Ni
[1]4uwd.a un919 . . . . . . . . . . . . . . . . . . . . . . E . . . . . . . . . . . . . . . . . . Mn
[1]5a3u.a r8j20 - - - - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mn
[1]5l9b.a PYIPMDDDFQL95 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mn
[1]5l9r.a oga,pg423 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]5l9v.a oga,PAAGDTIISL76 . . . . . . . . . . C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]5las.b oga,PAAGDTIISL76 . . . . . . . . . . C . . . . . . . . . . . . . . . . . . . . . . . . . . T . - - Mn
[1]5lb6.a un919 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . R Mn
[1]5lbb.a un919 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . T . . - Mn
[1]5lbc.a un919 . . . . . . . . . V L V . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]5lbe.a un919 . . . . . . . . . . . . . E . . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]5lbf.a un919 . . . . . . . . . . . . K E . . . . . . . . . . . . . . . . . . . . . . . . . . . Mn
[1]5ox5.a b2e18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Mn
[1]5ox6.a a1z21 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mn
[2]3ouj.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - . Fe
[2]4kbz.a 1qa28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Fe
[2]5v18.a 8uy17 . . . . - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - . Fe
[3]4bqy.a fnt20 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - Fe

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 Me
G
2
3
8
Q
2
3
9
L
2
4
0
V
2
4
1
S
2
4
2
R
2
5
2
D
2
5
4
I
2
5
6
W
2
5
8
E
2
6
0
K
2
6
2
D
2
7
7
I
2
8
0
R
2
8
1
I
2
9
2
N
2
9
3
G
2
9
4
R
2
9
5
T
2
9
6
K
2
9
7
M
2
9
9
A
3
0
1
Y
3
0
3
Y
3
1
0
H
3
1
3
D
3
1
5
D
3
2
0
R
3
2
2
I
3
2
7
Y
3
2
9
N
3
3
1
L
3
4
3
P
3
5
8
H
3
7
4
V
3
7
6
R
3
8
3
Y
3
8
4
A
3
8
5
W
3
8
9
Y
3
9
0
F
3
9
1
R
3
9
6
K
4
0
0
Y
4
0
3
L
4
0
4
T
4
0
5
G
4
0
6
E
4
0
7
K
4
0
8
G
4
0
9
V
4
1
0
R
4
1
1
V
4
1
2
E
4
1
3
L
4
1
4
N
4
1
5
[1]2g1m.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . . . . - - - - - - - - - - - - Fe
[1]2y33.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . . - - - - - - - - - - - - Zn
[1]2y34.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . - - - - - - - - - - - - - Fe
[1]3hqr.a . . . * . * * . . . . . . . . . . . . . . . * * . . . . . . . . . . . * . . . . . * . . . . . . . - - - - - - - Mn
[1]3hqu.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . - - - - - - - - - - - - - Fe
[1]3ouh.a . . . . . . . . . . . . . . . . . . . . . . * * . . . . . . . . . . . * . . . . . * . . - - - - - - - - - - - - Fe
[1]3oui.a . . - - - * * . . . . . . . . . . . . . . . * * . . - . . . . . . . . * . . . . . - - - - - - - - - - - - - - - Fe
[1]4bqw.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . . - - - - - - - - - - - - Mn
[1]4jzr.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . . . * - - - - - - - - - - - - - - Ni
[1]4uwd.a . . . . . . . . . . . . . . . . . . . . . . * . . E . . . . . . . . . * . . . . . . . . . - . . . . - - - - - - Mn
[1]5a3u.a - - - - - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * * . * . . . . . . . . Mn
[1]5l9b.a . . . . . * * . . . . . . . . . . . . . . . * * . . . . . . . . . . . * . . . . . * . . . . . . . . - - - - - - Mn
[1]5l9r.a . . . . . * * . . . . . . . . . . . . . . . * * . . . . . . . . . . . * . . . . . * . . . - - - - - - - - - - - Mn
[1]5l9v.a . . . . . * * . . . . . . C . . . . . . . . * * . . . . . . . . . . . * . . . . . . . . - - - - - - - - - - - - Mn
[1]5las.b . . . * . * * . . . . . . C . . . . . . . . * * . . . . . . . . . . . * . . . . . T . - - - - - - - - - - - - - Mn
[1]5lb6.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . . . K . V R - - - - - - - Mn
[1]5lbb.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . T . . . . . - - . . . . . . - Mn
[1]5lbc.a . . . . . . . . . . . . V L V . . . . . . . * . . . . . . . . . . . . * . . . . . * . . . - - - - - . . . . . - Mn
[1]5lbe.a . . . . . . . . . . . . . . . . E . . . . . * . . . . . . . . . . . . * . . . . . * . . . - - - - . . . . . - - Mn
[1]5lbf.a . . . . . . . . . . . . . . . K E . . . . . * . . . . . . . . . . . . * . . . . . * . . . - - . . . . . . . - - Mn
[1]5ox5.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . . - - - - - - . . . . . - Mn
[1]5ox6.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . . . . . - - - . . . . . - - - Mn
[2]3ouj.a . . . . . * * . . . . . . . . . . . . . . . * * . . . . . . . . . . . * . . . . . * . - - - * * * * * * * * * * Fe
[2]4kbz.a . . . . . * . . . . . . . . . . . . . . . . * * . . . . . . . . . . . * . . . . . . . * - - - * * * L * * * * * Fe
[2]5v18.a . . . . . - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - - * * * * * * * * * - Fe
[3]4bqy.a . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . * . . . . . * . . . - - - - - * * * * - - Fe

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2g1m.a:4hg
2y33.a:un9
2y34.a:un9
3hqr.a:PYIPMDDDFQL,oga
3hqu.a:MDDDFQL,un9
3ouh.a:014
3oui.a:42z
4bqw.a:qnm
4jzr.a:4jr
4uwd.a:un9
5a3u.a:r8j
5l9b.a:PYIPMDDDFQL
5l9r.a:oga,pg4
5l9v.a:PAAGDTIISL,oga
5las.b:PAAGDTIISL,oga
5lb6.a:un9
5lbb.a:un9
5lbc.a:un9
5lbe.a:un9
5lbf.a:un9
5ox5.a:b2e
5ox6.a:a1z
3ouj.a is apo
4kbz.a:1qa
5v18.a:8uy
4bqy.a:fnt
[1] 2g1m.a
0.2
0.1 0.5 0.8 0.4 0.1 0.2 0.1 0.5 0.2 0.5 0 0 0.5 0.9 0.1 0 0.2 0.1 0.1 0.1 0.1 - 0.4 2.4 0.2
[1] 2y33.a 0.1
0
0.6 0.6 0.2 0 0.1 0.1 0.4 0.1 0.5 0.1 0 0.8 1.1 0.1 0 0.1 0.1 0.1 0.2 0 - 0.3 3.1 0.1
[1] 2y34.a 0.1 0
0
1.7 2.0 0 0.1 0.1 0.2 0.1 0.5 1.2 0 1.3 1.6 0.1 0.1 0.1 0.1 0.1 0.2 0 - 0.2 3.0 0.1
[1] 3hqr.a 3.8 3.5 4.6
0.3
5.0 0.4 1.1 4.4 2.8 3.8 1.4 0.6 0.1 1.2 1.6 3.7 3.5 3.4 3.4 3.5 3.4 1.3 - 2.2 4.8 3.7
[1] 3hqu.a 0.1 0.1 1.0 1.0
0.1
0.1 0.2 0.1 0.3 0.1 0.7 0.4 0 1.4 1.7 0 0 0.1 0 0.1 0.1 0 - 0.3 2.9 0.1
[1] 3ouh.a 0.7 0.5 1.6 1.1 1.3
0.1
0.4 0.7 1.1 0.7 1.2 0.4 0.2 2.5 2.3 0.7 0.5 0.5 0.7 0.7 1.0 0.4 - 0.4 3.8 0.6
[1] 3oui.a 1.5 1.6 1.6 0.8 1.9 0
0
2.2 0.6 2.1 1.0 0.2 0 0.2 0.5 2.1 1.9 1.9 1.9 1.9 1.7 0.3 - 0.2 3.2 1.6
[1] 4bqw.a 0.2 0.1 0.7 0.6 0.4 0 0.2
0
0.2 0 0.7 0 0 0.6 0.9 0 0 0 0 0 0 0 - 0.2 3.0 0.1
[1] 4jzr.a 0.3 0.5 1.0 0.9 0.4 0 0.1 0.1
0
0.4 0.4 0.1 0 1.2 1.5 0.3 0.3 0.1 0.2 0.1 0.1 0 - 0.2 2.4 0.3
[1] 4uwd.a 0.2 0 0.1 0.6 0.7 0 0.1 0.1 0.1
0
0.5 0 0 0.4 0.5 0 0 0 0 0 0 0 - 0.2 3.4 0.1
[1] 5a3u.a 0.1 0 0.5 4.3 5.6 0 0 0.1 0.1 0
0
5.0 0 1.5 1.9 0 0 0 0 0 0.1 0 - 0.2 0.5 0.1
[1] 5l9b.a 2.7 2.9 3.8 1.0 3.8 0.3 0.4 3.4 1.9 2.9 1.4
0.2
0.1 1.1 1.6 2.8 2.9 2.7 2.8 2.8 2.4 1.0 - 1.1 3.8 2.8
[1] 5l9r.a 2.4 2.0 2.0 1.0 3.8 0 0.3 2.9 1.0 2.6 1.0 0.5
0
0.4 0.8 2.6 2.6 2.3 2.6 2.6 2.6 0.4 - 0.2 3.7 1.9
[1] 5l9v.a 2.9 2.7 2.2 0.9 3.1 0.2 0.3 3.3 1.2 3.3 1.0 0.2 0
0
0.1 3.0 3.2 3.2 3.2 3.2 2.9 0.8 - 1.1 3.5 2.4
[1] 5las.b 2.7 2.5 2.3 0.7 2.8 0.2 0.3 3.3 1.3 3.4 1.2 0.2 0 0.1
0
3.0 3.1 3.1 3.2 3.2 2.8 0.8 - 1.2 3.5 2.5
[1] 5lb6.a 0.2 0 0.6 0.7 0 0 0.2 0.1 0.2 0 0.4 0 0 0.3 0.7
0
0 0 0 0 0 0 - 0.2 2.8 0.1
[1] 5lbb.a 0.2 0 0 0.8 0.1 0 0.2 0.1 0.2 0 0.5 0 0 0 0 0
0
0 0 0 0 0 - 0.2 3.3 0.1
[1] 5lbc.a 0.2 0 0.6 0.7 0.3 0 0.1 0.1 0.4 0 0.4 0.1 0 0.4 0.7 0 0
0
0 0 0.1 0 - 0.2 3.1 0.1
[1] 5lbe.a 0.2 0 1.0 1.5 2.4 0 0.2 0.1 0.4 0 0.4 1.4 0.1 3.7 3.7 0 0 0
0
0 0 0 - 0.2 2.9 0.1
[1] 5lbf.a 0.2 0.2 1.1 1.5 1.7 0 0.2 0.1 0.1 0 0.7 1.1 0 2.8 2.7 0 0 0 0
0.1
0.1 0 - 0.2 3.2 0.2
[1] 5ox5.a 0.3 0.1 0.9 0.5 0.3 0 0.2 0 0.1 0.2 0.8 0 0 1.1 1.2 0.1 0.1 0.1 0.1 0.1
0
0.1 - 0.4 3.4 0.2
[1] 5ox6.a 0.2 0.4 1.0 0.9 0.3 0 0.2 0.3 0.4 0.3 0.9 0.3 0.1 1.1 1.0 0.3 0.2 0.3 0.3 0.3 0.3
0
- 0.3 3.3 0.2
[2] 3ouj.a 2.0 1.9 10 30 33 0.8 1.0 2.6 7.0 2.2 1.5 29 10 27 28 2.1 2.1 2.1 2.1 2.1 1.7 0.9
-
1.8 3.7 1.6
[2] 4kbz.a 2.1 2.2 12 29 33 0 0.1 2.4 6.6 2.9 0.8 25 9.9 25 24 2.9 2.4 2.4 2.7 2.5 2.1 0.6 -
0
3.2 2.2
[2] 5v18.a 0.4 0 8.7 30 30 0.8 0.7 0.2 6.4 0 1.1 28 9.7 27 27 0 0 0 0 0 0.1 0.4 - 2.0
0
0.3
[3] 4bqy.a 0.2 0 3.5 14 20 0 0.2 0.1 0.4 0.1 0.4 13 10 15 16 0.1 0.1 0.1 0.1 0.1 0.1 0 - 0.2 3.0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (3 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2g1m.a
2y33.a
2y34.a
3hqr.a
3hqu.a
3ouh.a
3oui.a
4bqw.a
4jzr.a
4uwd.a
5a3u.a
5l9b.a
5l9r.a
5l9v.a
5las.b
5lb6.a
5lbb.a
5lbc.a
5lbe.a
5lbf.a
5ox5.a
5ox6.a
3ouj.a
4kbz.a
5v18.a
4bqy.a
[1] 2g1m.a
0
.03 .05 .19 .04 .07 .09 .03 .03 .04 .18 .14 .12 .12 .13 .03 .05 .03 .09 .08 .04 .04 .78 .78 .76 .39
[1] 2y33.a .03
0
.04 .17 .04 .05 .09 .02 .03 .02 .19 .12 .10 .11 .11 .02 .04 .01 .09 .06 .03 .02 .76 .76 .77 .38
[1] 2y34.a .05 .04
0
.18 .03 .04 .10 .04 .04 .04 .19 .13 .12 .13 .14 .04 .06 .04 .07 .06 .04 .04 .76 .76 .78 .41
[1] 3hqr.a .19 .17 .18
0
.17 .16 .16 .17 .19 .17 .33 .10 .10 .09 .10 .18 .18 .18 .23 .20 .16 .17 .80 .76 .92 .54
[1] 3hqu.a .04 .04 .03 .17
0
.05 .09 .03 .03 .04 .18 .12 .11 .13 .14 .03 .05 .04 .07 .06 .03 .04 .75 .75 .76 .40
[1] 3ouh.a .07 .05 .04 .16 .05
0
.10 .06 .06 .05 .21 .12 .10 .12 .14 .06 .08 .05 .09 .07 .06 .04 .76 .75 .79 .41
[1] 3oui.a .09 .09 .10 .16 .09 .10
0
.08 .09 .07 .23 .10 .07 .08 .07 .07 .06 .08 .14 .13 .08 .09 .74 .73 .82 .44
[1] 4bqw.a .03 .02 .04 .17 .03 .06 .08
0
.03 .02 .18 .13 .10 .11 .12 .01 .03 .02 .09 .06 .02 .03 .76 .75 .77 .37
[1] 4jzr.a .03 .03 .04 .19 .03 .06 .09 .03
0
.03 .16 .14 .11 .13 .14 .02 .06 .03 .09 .07 .04 .04 .77 .75 .74 .39
[1] 4uwd.a .04 .02 .04 .17 .04 .05 .07 .02 .03
0
.18 .12 .09 .11 .13 .02 .03 .02 .09 .06 .02 .03 .75 .74 .77 .38
[1] 5a3u.a .18 .19 .19 .33 .18 .21 .23 .18 .16 .18
0
.28 .26 .28 .29 .18 .21 .18 .22 .20 .18 .19 .84 .84 .75 .54
[1] 5l9b.a .14 .12 .13 .10 .12 .12 .10 .13 .14 .12 .28
0
.08 .07 .07 .14 .13 .13 .17 .16 .12 .13 .75 .74 .86 .49
[1] 5l9r.a .12 .10 .12 .10 .11 .10 .07 .10 .11 .09 .26 .08
0
.07 .08 .10 .11 .09 .16 .14 .09 .09 .73 .70 .84 .45
[1] 5l9v.a .12 .11 .13 .09 .13 .12 .08 .11 .13 .11 .28 .07 .07
0
.02 .12 .10 .11 .18 .16 .12 .12 .76 .74 .86 .47
[1] 5las.b .13 .11 .14 .10 .14 .14 .07 .12 .14 .13 .29 .07 .08 .02
0
.12 .10 .11 .19 .17 .13 .13 .77 .75 .86 .48
[1] 5lb6.a .03 .02 .04 .18 .03 .06 .07 .01 .02 .02 .18 .14 .10 .12 .12
0
.04 .01 .08 .06 .03 .03 .76 .76 .76 .37
[1] 5lbb.a .05 .04 .06 .18 .05 .08 .06 .03 .06 .03 .21 .13 .11 .10 .10 .04
0
.04 .11 .09 .03 .06 .77 .76 .79 .40
[1] 5lbc.a .03 .01 .04 .18 .04 .05 .08 .02 .03 .02 .18 .13 .09 .11 .11 .01 .04
0
.09 .07 .03 .02 .76 .76 .77 .37
[1] 5lbe.a .09 .09 .07 .23 .07 .09 .14 .09 .09 .09 .22 .17 .16 .18 .19 .08 .11 .09
0
.03 .08 .10 .81 .81 .82 .45
[1] 5lbf.a .08 .06 .06 .20 .06 .07 .13 .06 .07 .06 .20 .16 .14 .16 .17 .06 .09 .07 .03
0
.06 .08 .79 .78 .80 .42
[1] 5ox5.a .04 .03 .04 .16 .03 .06 .08 .02 .04 .02 .18 .12 .09 .12 .13 .03 .03 .03 .08 .06
0
.03 .75 .74 .77 .39
[1] 5ox6.a .04 .02 .04 .17 .04 .04 .09 .03 .04 .03 .19 .13 .09 .12 .13 .03 .06 .02 .10 .08 .03
0
.76 .75 .77 .39
[2] 3ouj.a .78 .76 .76 .80 .75 .76 .74 .76 .77 .75 .84 .75 .73 .76 .77 .76 .77 .76 .81 .79 .75 .76
0
.14 .20 .44
[2] 4kbz.a .78 .76 .76 .76 .75 .75 .73 .75 .75 .74 .84 .74 .70 .74 .75 .76 .76 .76 .81 .78 .74 .75 .14
0
.24 .45
[2] 5v18.a .76 .77 .78 .92 .76 .79 .82 .77 .74 .77 .75 .86 .84 .86 .86 .76 .79 .77 .82 .80 .77 .77 .20 .24
0
.43
[3] 4bqy.a .39 .38 .41 .54 .40 .41 .44 .37 .39 .38 .54 .49 .45 .47 .48 .37 .40 .37 .45 .42 .39 .39 .44 .45 .43
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 2.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2g1m.a
2y33.a
2y34.a
3hqr.a
3hqu.a
3ouh.a
3oui.a
4bqw.a
4jzr.a
4uwd.a
5a3u.a
5l9b.a
5l9r.a
5l9v.a
5las.b
5lb6.a
5lbb.a
5lbc.a
5lbe.a
5lbf.a
5ox5.a
5ox6.a
3ouj.a
4kbz.a
5v18.a
4bqy.a
[1] 2g1m.a
0
1.0 0.7 4.5 0.6 0.9 2.0 0.9 0.3 0.5 1.2 4.5 3.4 4.3 4.3 0.8 0.7 0.9 0.7 0.6 0.9 0.7 3.5 3.7 3.4 0.8
[1] 2y33.a 1.0
0
0.4 4.5 0.4 0.8 2.0 0.2 0.3 0.7 0.9 4.5 3.4 4.3 4.4 0.4 0.5 0.3 0.5 0.6 0.3 0.5 3.5 3.6 3.4 0.4
[1] 2y34.a 0.7 0.4
0
4.5 0.3 0.8 2.0 0.5 0.3 0.5 0.9 4.4 3.3 4.3 4.3 0.5 0.5 0.5 0.6 0.6 0.5 0.5 3.3 3.4 3.3 0.4
[1] 3hqr.a 4.5 4.5 4.5
0
4.5 4.1 1.4 4.5 4.5 6.7 4.5 1.0 2.1 0.7 0.7 6.7 4.9 4.5 4.5 5.8 4.5 5.1 5.6 5.2 5.9 4.4
[1] 3hqu.a 0.6 0.4 0.3 4.5
0
0.8 2.0 0.5 0.3 0.5 1.0 4.5 3.4 4.4 4.3 0.4 0.5 0.4 0.5 0.5 0.5 0.5 3.4 3.5 3.4 0.4
[1] 3ouh.a 0.9 0.8 0.8 4.1 0.8
0
1.9 0.8 0.5 0.8 0.9 4.1 3.2 4.0 4.0 0.8 0.7 0.8 0.8 0.7 0.8 0.6 3.3 3.4 3.2 0.7
[1] 3oui.a 2.0 2.0 2.0 1.4 2.0 1.9
0
2.0 2.0 2.0 1.4 1.3 1.0 1.2 1.2 2.0 2.0 2.0 2.1 2.1 2.1 1.9 1.1 1.1 1.3 2.0
[1] 4bqw.a 0.9 0.2 0.5 4.5 0.5 0.8 2.0
0
0.3 0.7 0.9 4.5 3.4 4.4 4.4 0.4 0.4 0.4 0.5 0.5 0.2 0.4 3.5 3.6 3.4 0.4
[1] 4jzr.a 0.3 0.3 0.3 4.5 0.3 0.5 2.0 0.3
0
0.3 0.9 4.4 3.3 4.3 4.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 3.4 3.5 3.3 0.3
[1] 4uwd.a 0.5 0.7 0.5 6.7 0.5 0.8 2.0 0.7 0.3
0
4.5 7.5 3.3 4.3 4.3 0.7 2.4 0.8 1.5 2.5 0.7 2.2 7.6 7.2 7.6 0.6
[1] 5a3u.a 1.2 0.9 0.9 4.5 1.0 0.9 1.4 0.9 0.9 4.5
0
5.5 1.9 1.0 1.0 4.4 5.4 4.9 4.7 4.6 5.0 4.1 12 12 11 8.3
[1] 5l9b.a 4.5 4.5 4.4 1.0 4.5 4.1 1.3 4.5 4.4 7.5 5.5
0
2.1 0.7 0.6 6.5 6.0 4.4 5.7 6.6 4.5 5.9 6.8 6.4 7.0 4.4
[1] 5l9r.a 3.4 3.4 3.3 2.1 3.4 3.2 1.0 3.4 3.3 3.3 1.9 2.1
0
1.8 1.8 3.4 3.4 3.4 3.4 3.4 3.4 3.3 0.9 1.5 0.9 3.4
[1] 5l9v.a 4.3 4.3 4.3 0.7 4.4 4.0 1.2 4.4 4.3 4.3 1.0 0.7 1.8
0
0.2 4.4 4.3 4.3 4.4 4.4 4.4 4.3 2.0 2.2 2.2 4.3
[1] 5las.b 4.3 4.4 4.3 0.7 4.3 4.0 1.2 4.4 4.3 4.3 1.0 0.6 1.8 0.2
0
4.4 4.4 4.4 4.4 4.5 4.4 4.3 2.0 2.0 2.2 4.4
[1] 5lb6.a 0.8 0.4 0.5 6.7 0.4 0.8 2.0 0.4 0.3 0.7 4.4 6.5 3.4 4.4 4.4
0
1.1 0.3 0.3 2.2 0.4 1.7 6.8 6.3 6.8 0.1
[1] 5lbb.a 0.7 0.5 0.5 4.9 0.5 0.7 2.0 0.4 0.3 2.4 5.4 6.0 3.4 4.3 4.4 1.1
0
0.9 2.5 2.5 0.7 2.1 8.4 8.3 8.6 5.8
[1] 5lbc.a 0.9 0.3 0.5 4.5 0.4 0.8 2.0 0.4 0.3 0.8 4.9 4.4 3.4 4.3 4.4 0.3 0.9
0
2.0 2.0 0.6 1.6 8.7 8.7 8.9 6.2
[1] 5lbe.a 0.7 0.5 0.6 4.5 0.5 0.8 2.1 0.5 0.3 1.5 4.7 5.7 3.4 4.4 4.4 0.3 2.5 2.0
0
0.3 2.2 0.7 9.1 9.1 9.2 7.9
[1] 5lbf.a 0.6 0.6 0.6 5.8 0.5 0.7 2.1 0.5 0.3 2.5 4.6 6.6 3.4 4.4 4.5 2.2 2.5 2.0 0.3
0
2.3 0.9 9.4 9.4 9.6 8.0
[1] 5ox5.a 0.9 0.3 0.5 4.5 0.5 0.8 2.1 0.2 0.3 0.7 5.0 4.5 3.4 4.4 4.4 0.4 0.7 0.6 2.2 2.3
0
1.8 8.4 8.4 8.6 6.0
[1] 5ox6.a 0.7 0.5 0.5 5.1 0.5 0.6 1.9 0.4 0.3 2.2 4.1 5.9 3.3 4.3 4.3 1.7 2.1 1.6 0.7 0.9 1.8
0
7.7 7.7 7.8 6.1
[2] 3ouj.a 3.5 3.5 3.3 5.6 3.4 3.3 1.1 3.5 3.4 7.6 12 6.8 0.9 2.0 2.0 6.8 8.4 8.7 9.1 9.4 8.4 7.7
0
0.4 0.8 3.3
[2] 4kbz.a 3.7 3.6 3.4 5.2 3.5 3.4 1.1 3.6 3.5 7.2 12 6.4 1.5 2.2 2.0 6.3 8.3 8.7 9.1 9.4 8.4 7.7 0.4
0
0.5 3.5
[2] 5v18.a 3.4 3.4 3.3 5.9 3.4 3.2 1.3 3.4 3.3 7.6 11 7.0 0.9 2.2 2.2 6.8 8.6 8.9 9.2 9.6 8.6 7.8 0.8 0.5
0
3.3
[3] 4bqy.a 0.8 0.4 0.4 4.4 0.4 0.7 2.0 0.4 0.3 0.6 8.3 4.4 3.4 4.3 4.4 0.1 5.8 6.2 7.9 8.0 6.0 6.1 3.3 3.5 3.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 2.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2g1m.a
2y33.a
2y34.a
3hqr.a
3hqu.a
3ouh.a
3oui.a
4bqw.a
4jzr.a
4uwd.a
5a3u.a
5l9b.a
5l9r.a
5l9v.a
5las.b
5lb6.a
5lbb.a
5lbc.a
5lbe.a
5lbf.a
5ox5.a
5ox6.a
3ouj.a
4kbz.a
5v18.a
4bqy.a
[1] 2g1m.a
0
1.3 1.0 4.4 0.7 1.9 2.8 1.2 0.6 1.0 1.8 4.5 3.5 4.6 4.4 0.9 0.8 1.0 0.9 0.9 1.2 1.8 3.5 4.1 3.3 0.9
[1] 2y33.a 1.3
0
0.8 4.4 0.9 1.5 2.8 0.4 0.7 0.9 1.4 4.4 3.5 4.5 4.3 0.5 0.6 0.7 0.7 0.8 0.5 1.4 3.6 3.9 3.3 0.7
[1] 2y34.a 1.0 0.8
0
4.4 0.8 1.2 2.8 0.9 0.9 0.8 1.4 4.3 3.3 4.3 4.3 0.8 0.8 0.9 0.9 1.0 0.7 1.0 3.5 3.6 3.2 0.9
[1] 3hqr.a 4.4 4.4 4.4
0
4.4 4.2 2.3 4.4 4.4 5.9 3.9 1.2 2.5 1.6 0.8 6.1 4.7 4.4 4.4 5.2 4.3 4.7 5.8 5.7 6.0 4.4
[1] 3hqu.a 0.7 0.9 0.8 4.4
0
1.0 2.8 0.9 0.5 0.9 1.4 4.4 3.4 4.3 4.3 0.8 0.8 0.9 0.9 0.9 0.8 0.9 3.6 3.6 3.3 0.9
[1] 3ouh.a 1.9 1.5 1.2 4.2 1.0
0
2.7 1.5 0.6 1.1 1.8 4.2 3.4 4.1 4.1 0.9 0.9 1.0 1.0 1.0 1.5 0.8 3.6 3.6 3.2 1.1
[1] 3oui.a 2.8 2.8 2.8 2.3 2.8 2.7
0
2.8 2.8 2.8 2.3 2.2 1.9 2.2 2.2 2.8 2.8 2.8 2.8 2.8 2.8 2.7 1.9 1.9 2.3 2.8
[1] 4bqw.a 1.2 0.4 0.9 4.4 0.9 1.5 2.8
0
0.7 0.9 1.4 4.4 3.5 4.5 4.3 0.5 0.5 0.6 0.7 0.8 0.5 1.4 3.7 4.0 3.3 0.7
[1] 4jzr.a 0.6 0.7 0.9 4.4 0.5 0.6 2.8 0.7
0
0.9 1.3 4.4 3.4 4.4 4.3 0.7 0.7 0.7 0.7 0.7 0.6 0.7 3.4 3.4 3.2 0.7
[1] 4uwd.a 1.0 0.9 0.8 5.9 0.9 1.1 2.8 0.9 0.9
0
3.6 6.3 3.3 4.3 4.3 0.9 1.8 1.0 1.2 2.0 0.9 1.8 6.2 6.0 6.1 1.0
[1] 5a3u.a 1.8 1.4 1.4 3.9 1.4 1.8 2.3 1.4 1.3 3.6
0
4.6 2.1 1.9 1.4 3.6 5.1 4.8 4.2 4.4 4.6 3.6 12 12 9.9 7.9
[1] 5l9b.a 4.5 4.4 4.3 1.2 4.4 4.2 2.2 4.4 4.4 6.3 4.6
0
2.5 1.6 0.7 5.8 5.2 4.4 5.0 5.6 4.3 5.1 5.6 5.4 5.8 4.4
[1] 5l9r.a 3.5 3.5 3.3 2.5 3.4 3.4 1.9 3.5 3.4 3.3 2.1 2.5
0
2.3 2.2 3.4 3.4 3.5 3.4 3.4 3.4 3.4 1.0 1.9 1.4 3.4
[1] 5l9v.a 4.6 4.5 4.3 1.6 4.3 4.1 2.2 4.5 4.4 4.3 1.9 1.6 2.3
0
0.3 4.4 4.3 4.4 4.4 4.3 4.4 4.1 2.8 2.8 2.8 4.4
[1] 5las.b 4.4 4.3 4.3 0.8 4.3 4.1 2.2 4.3 4.3 4.3 1.4 0.7 2.2 0.3
0
4.4 4.3 4.4 4.4 4.3 4.2 4.2 2.4 2.4 2.8 4.3
[1] 5lb6.a 0.9 0.5 0.8 6.1 0.8 0.9 2.8 0.5 0.7 0.9 3.6 5.8 3.4 4.4 4.4
0
0.9 0.6 0.6 1.8 0.5 1.4 6.0 5.8 6.0 0.4
[1] 5lbb.a 0.8 0.6 0.8 4.7 0.8 0.9 2.8 0.5 0.7 1.8 5.1 5.2 3.4 4.3 4.3 0.9
0
1.0 2.2 2.3 0.7 1.9 8.1 8.1 8.2 5.1
[1] 5lbc.a 1.0 0.7 0.9 4.4 0.9 1.0 2.8 0.6 0.7 1.0 4.8 4.4 3.5 4.4 4.4 0.6 1.0
0
1.7 1.8 0.7 1.4 8.3 8.3 8.4 5.1
[1] 5lbe.a 0.9 0.7 0.9 4.4 0.9 1.0 2.8 0.7 0.7 1.2 4.2 5.0 3.4 4.4 4.4 0.6 2.2 1.7
0
0.6 1.9 0.8 7.8 7.8 7.8 6.8
[1] 5lbf.a 0.9 0.8 1.0 5.2 0.9 1.0 2.8 0.8 0.7 2.0 4.4 5.6 3.4 4.3 4.3 1.8 2.3 1.8 0.6
0
1.9 0.8 8.4 8.3 8.5 7.5
[1] 5ox5.a 1.2 0.5 0.7 4.3 0.8 1.5 2.8 0.5 0.6 0.9 4.6 4.3 3.4 4.4 4.2 0.5 0.7 0.7 1.9 1.9
0
1.9 7.6 7.7 7.7 4.9
[1] 5ox6.a 1.8 1.4 1.0 4.7 0.9 0.8 2.7 1.4 0.7 1.8 3.6 5.1 3.4 4.1 4.2 1.4 1.9 1.4 0.8 0.8 1.9
0
6.4 6.2 6.4 4.9
[2] 3ouj.a 3.5 3.6 3.5 5.8 3.6 3.6 1.9 3.7 3.4 6.2 12 5.6 1.0 2.8 2.4 6.0 8.1 8.3 7.8 8.4 7.6 6.4
0
0.8 1.3 3.6
[2] 4kbz.a 4.1 3.9 3.6 5.7 3.6 3.6 1.9 4.0 3.4 6.0 12 5.4 1.9 2.8 2.4 5.8 8.1 8.3 7.8 8.3 7.7 6.2 0.8
0
1.2 3.7
[2] 5v18.a 3.3 3.3 3.2 6.0 3.3 3.2 2.3 3.3 3.2 6.1 9.9 5.8 1.4 2.8 2.8 6.0 8.2 8.4 7.8 8.5 7.7 6.4 1.3 1.2
0
3.2
[3] 4bqy.a 0.9 0.7 0.9 4.4 0.9 1.1 2.8 0.7 0.7 1.0 7.9 4.4 3.4 4.4 4.3 0.4 5.1 5.1 6.8 7.5 4.9 4.9 3.6 3.7 3.2
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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