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EGFR_HUMAN_984_1022

Epidermal growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

Composition of the binding site

Protein chains monomer
A1 (EGFR_HUMAN):986:989807:809, 986:989

Full PDB list

1m17, 1xkk, 2eb2, 2eb3, 2gs2, 2gs6, 2itn, 2ito, 2itt, 2itu, 2itv, 2itx, 2ity, 2itz, 2j5e, 2j5f, 3gop, 3gt8, 3ika, 3poz, 3ug2, 3w2p, 3w2q, 3w2r, 3w2s, 3w32, 3w33, 4g5j, 4i22, 4i23, 4i24, 4lqm, 4r3p, 4r3r, 4r5s, 4rj4, 4rj5, 4rj6, 4rj7, 4rj8, 4tks, 4zse, 5c8k, 5c8m, 5c8n, 5cal, 5can, 5cao, 5cap, 5caq, 5cas, 5cau, 5cnn, 5cno, 5czh, 5czi, 5d41, 5edp, 5edq, 5edr, 5em5, 5em6, 5em7, 5em8, 5gmp, 5gty, 5gtz, 5hcx, 5hcy, 5hcz, 5hib, 5hic, 5ugb, 5xgm (redundant Pocketome entry); 1m14, 2gs7, 2itp, 2itq, 2itw, 2j6m, 2jit, 2jiu, 2jiv, 2rf9, 2rfe, 2rgp, 3bel, 3ug1, 3vjn, 3vjo, 3w2o, 4g5p, 4hjo, 4i1z, 4i20, 4i21, 4jq7, 4jq8, 4jr3, 4jrv, 4li5, 4riw, 4rix, 4riy, 4wd5, 4wkq, 4wrg, 4zau, 4zjv, 5cav, 5fed, 5fee, 5feq, 5hg5, 5hg7, 5hg8, 5hg9, 5j9y, 5j9z, 5jeb, 5u8l, 5ug8, 5ug9, 5uga, 5ugc, 5uwd, 5xgn (unprocessed)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
N
8
0
8
R
9
8
6
M
9
8
7
H
9
8
8
L
9
8
9
[1]4g5j.a 0wm34 . . . . .
[2]5cno.a none . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
D
8
0
7
N
8
0
8
I
8
0
9
R
9
8
6
M
9
8
7
H
9
8
8
L
9
8
9
[1]4g5j.a . . . . . . .
[2]5cno.a . * . . * . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4g5j.a:0wm
5cno.a is apo
[1] 4g5j.a
0
-
[2] 5cno.a 3.2
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4g5j.a
5cno.a
[1] 4g5j.a
0
.29
[2] 5cno.a .29
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 2.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4g5j.a
5cno.a
[1] 4g5j.a
0
4.0
[2] 5cno.a 4.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 2.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4g5j.a
5cno.a
[1] 4g5j.a
0
4.8
[2] 5cno.a 4.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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