If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

EF2_YEAST_1_842

Elongation factor 2 [TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily]

Composition of the binding site

Protein chains monomer
A1 (EF2_YEAST):465, 483:490, 517, 519, 521, 523, 524, 529, 531:538, 559:562, 564, 727, 729, 774, 777:781, 796:798, 801113, 465, 483:490, 517, 519, 521, 523, 524, 529, 531:538, 559:562, 564, 727, 729, 774, 777:781, 796:798, 801

Full PDB list

1n0u, 1n0v, 1u2r, 1zm2, 1zm3, 1zm4, 1zm9, 2e1r, 2npf, 2zit, 3b78, 3b82, 3b8h (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
P
4
8
7
V
4
8
8
Q
4
9
0
L
5
1
9
Y
5
2
1
S
5
2
3
E
5
2
4
I
5
2
9
P
5
5
9
V
5
6
0
V
5
6
1
A
5
6
2
R
5
6
4
P
7
2
7
F
7
2
9
V
7
7
4
S
7
7
7
G
7
7
9
F
7
8
0
T
7
8
1
M
7
9
6
V
7
9
7
F
7
9
8
W
8
0
1
[1]1n0u.a so135 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2e1r.a sod36 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2npf.a mou49 . . . . . . . . . . . . . . . . . . . . . . . .
[2]1zm4.a none . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
S
1
1
3
K
4
6
5
F
4
8
3
S
4
8
4
V
4
8
5
S
4
8
6
P
4
8
7
V
4
8
8
V
4
8
9
Q
4
9
0
C
5
1
7
L
5
1
9
Y
5
2
1
S
5
2
3
E
5
2
4
I
5
2
9
A
5
3
1
G
5
3
2
T
5
3
3
G
5
3
4
E
5
3
5
L
5
3
6
H
5
3
7
L
5
3
8
P
5
5
9
V
5
6
0
V
5
6
1
A
5
6
2
R
5
6
4
P
7
2
7
F
7
2
9
V
7
7
4
S
7
7
7
F
7
7
8
G
7
7
9
F
7
8
0
T
7
8
1
M
7
9
6
V
7
9
7
F
7
9
8
W
8
0
1
[1]1n0u.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2e1r.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2npf.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]1zm4.a . . . . . * * * * . . . . . . . . . * . * . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1n0u.a:so1
2e1r.a:sod
2npf.a:mou
1zm4.a is apo
[1] 1n0u.a
0
0.1 1.1 -
[1] 2e1r.a 0
0
0.9 -
[1] 2npf.a 0 0.1
0.1
-
[2] 1zm4.a 14 14 16
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1n0u.a
2e1r.a
2npf.a
1zm4.a
[1] 1n0u.a
0
.02 .03 .41
[1] 2e1r.a .02
0
.02 .40
[1] 2npf.a .03 .02
0
.42
[2] 1zm4.a .41 .40 .42
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1n0u.a
2e1r.a
2npf.a
1zm4.a
[1] 1n0u.a
0
1.5 1.4 12
[1] 2e1r.a 1.5
0
0.7 12
[1] 2npf.a 1.4 0.7
0
12
[2] 1zm4.a 12 12 12
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1n0u.a
2e1r.a
2npf.a
1zm4.a
[1] 1n0u.a
0
1.7 1.7 12
[1] 2e1r.a 1.7
0
0.9 12
[1] 2npf.a 1.7 0.9
0
12
[2] 1zm4.a 12 12 12
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...