EED_HUMAN_77_441

Polycomb protein EED [WD repeat ESC family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (EED_HUMAN):R: Interaction with EZH2 (95,97,148,194,306:308,324,362:365,382,411,414,430)
R: Required for interaction with the matrix protein MA of HIV-1 (194)
R: Required for interaction with the matrix protein MA of HIV-1 (306:308,324,362:365,382,411,414,430)
95,97,148,194,306:308,324,362:365,382,411,414,430

Full PDB list

2qxv,3iiw,3iiy,3ij0,3ij1,3ijc,3jpx,3jzg,3jzh,3jzn,3k26,3k27,4x3e,5hyn,5ij7,5ij8 (redundant pocketome entry)

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
P
9
5
F
9
7
Y
1
4
8
N
1
9
4
R
3
0
6
N
3
0
7
Y
3
0
8
C
3
2
4
D
3
6
2
I
3
6
3
W
3
6
4
Y
3
6
5
Q
3
8
2
A
4
1
1
R
4
1
4
D
4
3
0
[1]5ij7.f none . . . . . . . . . . . . . . . .
[1]3ijc.a nds 12 . . . . . . . . . . . . . . . .
[1]3iiw.a ARm3lSA 39 . . . . . . . . . . . . . . . .
[1]3iiy.a ARm3lSAGAA 53 . . . . . . . . . . . . . . . .
[1]3ij0.a ARm3lST 41 . . . . . . . . . . . . . . . .
[1]3ij1.a RHRm3lVLR 70 . . . . . . . . . . . . . . . .
[1]3jpx.a HRm3lVLR 59 . . . . . . . . . . . . . . . .
[1]3jzg.a ARm3lS 34 . . . . . . . . . . . . . . . .
[1]3jzh.a DFm3lTD 46 . . . . . . . . . . . . . . . .
[1]3k26.a m3lQ 21 . . . . . . . . . . . . . . . .
[1]3k27.a TARm3lSTG 52 . . . . . . . . . . . . . . . .
[1]4x3e.a AQRm3lFAQS 68 . . . . . . . . . . . . . . . .
[1]5hyn.b I-GD,RLQAQRm3lFAQS 116 . . . . . . . . . . . . . . . .
[1]5hyn.g LQAQRm3lFAQS 85 . . . . . . . . . . . . . . . .
[1]5hyn.l QAQRm3lFAQS 77 . . . . . . . . . . . . . . . .
[1]5hyn.r I-DEVL,LQAQRm3lFAQS 125 . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
Similar entries
Feedback