E2AK2_HUMAN_255_551_ATPsite

Interferon-induced, double-stranded RNA-activated protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (E2AK2_HUMAN):R: Interaction with TRAF5 (273,274,281,294,296,366:369,419,421,432)
D: Protein kinase (273,274,281,294,296,366:369,419,421,432)
273,274,281,294,296,366:369,419,421,432

Full PDB list

2a19,2a1a,3uiu

Contact map

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ligand
A1
I
2
7
3
G
2
7
4
V
2
8
1
V
2
9
4
K
2
9
6
M
3
6
6
E
3
6
7
F
3
6
8
C
3
6
9
N
4
1
9
F
4
2
1
D
4
3
2
[1]2a19.b anp,mg 32 . . . . . . . . . . . .
[1]2a19.c anp,mg,mg 33 . . . . . . . . . . . .
[1]2a1a.b none . . . . . . . . . . . .
[1]3uiu.a none . . . . R . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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